Muscle-Strengthening Activity and Its Association With Insulin Sensitivity

Diabetes Translation, Centers for Disease Control and Prevention, Atlanta, Georgia 30341, USA.
Diabetes care (Impact Factor: 8.42). 10/2007; 30(9):2264-70. DOI: 10.2337/dc07-0372
Source: PubMed


Muscle-strengthening activities (MSAs) may increase insulin sensitivity, thereby reducing the risk of diabetes. The purpose of this study was to assess the relationship between MSAs and insulin sensitivity among American adults.
We analyzed data on 4,504 adults without diabetes, aged 20-79 years, who participated in the National Health and Nutrition Examination Survey 1999-2004 and had information on MSAs. Self-reported frequency (times/week) of MSAs was grouped as low (<1), moderate (1-2.9), or high (>or=3). Insulin sensitivity was measured by the fasting quantitative insulin sensitivity check index x 100 (QUICKI).
After adjustment for age, race/ethnicity, physical activity other than MSAs, BMI, smoking, alcohol consumption, and daily total caloric intake, the mean values for QUICKI by low, moderate, and high MSA were 33.6, 33.9, and 34.2, respectively (P for linear trend = 0.008) for men and 34.2, 34.6, 34.6, respectively (P for linear trend = 0.009) for women. Mean fasting insulin (picomols per liter) concentrations were 75.0, 68.9, and 65.9, respectively (P for linear trend = 0.017) for men and 66.9, 63.3, 61.2, respectively (P for linear trend = 0.007) for women. There were no significant differences across MSA groups for fasting glucose among men or women.
MSA is independently associated with higher insulin sensitivity among U.S. adults. Efforts to increase MSA may be a realistic, feasible, and effective method of reducing insulin resistance among the U.S. population.

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    • "In the main part of the analysis, PA was assessed by a single question with responses measured on a 3-point Likert scale, which asked whether the subject was less active (score = 1), about the same (score = 2) or more active (score = 3) than his age peers. This single question was validated against a more objective measure which was MET × h/week of PA (Cheng et al., 2007; Lagerros and Lagiou, 2007; McCullough et al., 2000). This measure was constructed based on individual leisure-time activities that were given an intensity score assessed by the metabolic equivalent or MET which was further multiplied by duration of this particular activity and frequency converted to per week unit. "
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    • "d fat mass , and in - creased fat - free and skeletal mass by 2 . 6 kg and 4 . 2 kg , respectively ( Abe et al . 2003 ) . Compared with the low - est category , men in the highest strength group had 44% lower risk of developing MS ( Jurca et al . 2005 ) . Strength training was also very important in improving insulin sensitivity in men and women ( Cheng et al . 2007 ) . As previously described , obesity , especially its ab - dominal pattern , increased the risk of hypertension and all pathologies of the MS . Greenfield et al . ( 2003 ) studied 684 female twins and reported that the group with regular engagement in recreational physical activ - ities had the same lowest blood pressure values found i"
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