Effect of tenofovir on renal glomerular and tubular function

Division of Infectious Diseases, University Hospital, Berne, Switzerland.
AIDS (Impact Factor: 6.56). 08/2007; 21(11):1483-5. DOI: 10.1097/QAD.0b013e328216f15b
Source: PubMed

ABSTRACT To evaluate tenofovir-related nephropathy, we quantified calculated glomerular filtration rates (GFR) and renal tubular function in 46 tenofovir-treated patients and 25 without tenofovir. We also analysed patients who stopped tenofovir for drug-related nephrotoxicity at our clinic. Tenofovir use combined with non-nucleoside reverse transcriptase inhibitors, but not with protease inhibitors, resulted in a significant increase in calculated GFR. Tenofovir use was associated with significantly lower phosphatemia and a marginally increased fractional excretion of uric acid, but no other signs of tubulopathy.

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