Nongenomic actions of low concentration estrogens and xenoestrogens on multiple tissues PMCID:17601655

Texas A&M University - Galveston, Galveston, Texas, United States
Molecular and Cellular Endocrinology (Impact Factor: 4.41). 09/2007; 274(1-2):1-7. DOI: 10.1016/j.mce.2007.05.011
Source: PubMed


Nongenomic estrogenic mechanisms offer an opportunity to explain the conundrum of environmental estrogen and plant estrogen effects on cells and animals at the very low concentrations which are prevalent in our environments and diets. Heretofore the actions of these compounds have not been adequately accounted for by laboratory tests utilizing assays for actions only via the genomic pathway of steroid action and the nuclear forms of estrogen receptor alpha and beta. Membrane versions of these receptors, and the newly described GPR30 (7TMER) receptor protein provide explanations for the more potent actions of xenoestrogens. The effects of estrogens on many tissues demand a comprehensive assessment of the receptors, receptor levels, and mechanisms that might be involved, to determine which of these estrogen mimetic compounds are harmful and which might even be used therapeutically, depending upon the life stage at which we are exposed to them.

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Available from: Cheryl Watson,
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    • "Overdoses of endogenous or exogenous estrogens (De Bosschere et al. 2002) may lead to various reproductive disorders , including ovarian dysfunction. Long-term exposure to high levels of estrogenic substances during maturation may result in ovarian dysfunction (hypostimulation due to the presence of ZEN in feed) (Gajęcka et al. 2004, Watson et al. 2007). ZEN and its metabolites are non-steroidal compounds that bind to estrogen receptors (ERs). "

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    • "In pre-pubertal bitches, the function of granulosa cells is easily deregulated during long-term exposure to ZEN which is ingested with commercial feed (Gajęcka et al. 2004, Skorska-Wyszyńska et al. 2004, Watson et al. 2007). ZEN disrupts the steroid hormone balance (systemic endocrine mechanisms), and it affects the activity of hydroxysteroid dehydrogenases (HSDs) at the pre-receptor level (local intracrine mechanisms). "

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    • "Overdosing of endogenous and exogenous (De Bosschere et al. 2002) oestrogens could lead to different reproductive system disorders associated with hyperestrogenism, and excess oestrogens could distort hormonal regulation of reproductive processes, contributing to numerous health problems during maturation (Gajęcka et al. 2008). During reproductive maturation, ovarian functions are easily deregulated under prolonged exposure to estrogenic substances in feed (Gajęcka et al. 2004, Watson et al. 2007). "

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