Microcystic urothelial carcinoma of the urinary bladder metastatic to the penis

Izmir Ataturk Training and Research Hospital, Department of Pathology, Izmir, Alsancak, 35220, Turkey.
Pathology & Oncology Research (Impact Factor: 1.86). 02/2007; 13(2):170-3. DOI: 10.1007/BF02893496
Source: PubMed


Metastatic spread of primary bladder cancer to the penis is an extremely rare event. Microcystic urothelial carcinoma is a very rare variant of urothelial carcinoma. Due to its rareness and insufficient clinical follow-up data, the prognosis of microcystic urothelial carcinoma is still not clear. Here in we report a case of a penile metastasis from microcystic urothelial carcinoma of urinary bladder, in a 56-year-old man who died 6 months after radical cystoprostatectomy and total penectomy. To the best of our knowledge this is the first case report of microcystic variant of urothelial carcinoma which has metastasized to the penis.

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    • "A second transurethral resection of bladder tumour was undertaken and histological examination of the specimen revealed that the tumour had infiltrated the muscularis propria. He was next referred to the institution where Sari and associates [13] worked. During admission to the second hospital, he developed visible haematuria and pain in his penis. "
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    ABSTRACT: . Microcystic variant of urothelial carcinoma is one of the new variants of urothelial carcinoma that was added to the WHO classification in 2004. Aims. To review the literature on microcystic variant of urothelial carcinoma. Methods. Various internet search engines were used to identify reported cases of the tumour. Results . Microscopic features of the tumour include: (i) Conspicuous intracellular and intercellular lumina/microcysts encompassed by malignant urothelial or squamous cells. (ii) The lumina are usually empty; may contain granular eosinophilic debris, mucin, or necrotic cells. (iii) The cysts may be variable in size; round, or oval, up to 2 mm; lined by urothelium which are either flattened cells or low columnar cells however, they do not contain colonic epithelium or goblet cells; are infiltrative; invade the muscularis propria; mimic cystitis cystica and cystitis glandularis; occasionally exhibit neuroendocrine differentiation. (iv) Elongated and irregular branching spaces are usually seen. About 17 cases of the tumour have been reported with only 2 patients who have survived. The tumour tends to be of high-grade and high-stage. There is no consensus opinion on the best option of treatment of the tumour. Conclusions . It would prove difficult at the moment to be dogmatic regarding its prognosis but it is a highly aggressive tumour. New cases of the tumour should be reported in order to document its biological behaviour.
    Advances in Urology 12/2013; 2013(5):654751. DOI:10.1155/2013/654751
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    • "Besides, the immunopositivity encountered in some elements in the accompanying high-grade urothelial carcinoma within the penile tumor seems to favor this hypothesis. In conclusion, the acquisition of microcystic histology seems to be associated with an aggressive clinical course of the urothelial carcinoma, as already suggested by other authors [7]. MUC5AC expression in association with the development of a microcystic appearance may indicate the likely derivation of this variant through a process of dedifferentiation and redifferentiation from transitional cell carcinoma. "
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    ABSTRACT: Microcystic urothelial carcinoma is a rare variant of transitional cell carcinoma with an indefinite prognostic significance. Herein, we report for the first time the acquisition of microcystic histology in the penile metastasis of a high-grade urothelial carcinoma of the urinary bladder. The patient died of disseminated disease six months later. The immunohistochemical evaluation of mucin expression in the primitive and metastatic tumor suggests that the microcystic histotype may descend from the primitive urothelial carcinoma through a process of dedifferentiation and subsequent redifferentiation. In conclusion, the acquisition of microcystic histology seems to be associated with an aggressive clinical course of the urothelial carcinoma, as already suggested by other authors. Future studies investigating mucin expression in microcystic urothelial carcinoma may help to define the histogenesis of this tumor.
    Pathology - Research and Practice 02/2009; 205(8):568-71. DOI:10.1016/j.prp.2008.12.005 · 1.40 Impact Factor
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    • "Les métastases au niveau de la verge sont difficiles à individualiser des diffusions par contiguïté. Néanmoins, de nombreux cas ont été décrit soit sous forme de nodule tumoral soit sous forme de priapisme [40] [41] [42]. Le plus souvent la métastase concerne le corps caverneux et parfois le gland, plus rarement le corps spongieux. "
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    ABSTRACT: The liver, the lungs lung and bone are the most frequent sites for urothelial carcinoma metastasis. Nevertheless many other areas have also been described. Using Pubmed and Cochrane the most exhaustive research possible has been carried out to list these secondary urothelial carcinoma lesions.
    Progrès en Urologie 11/2008; 18. DOI:10.1016/S1166-7087(08)74557-3 · 0.66 Impact Factor
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