Article

Identifying critical signaling molecules for the treatment of cancer.

Department of Medicine, Stanford University School of Medicine, CA 94305-5151, USA.
Recent results in cancer research. Fortschritte der Krebsforschung. Progrès dans les recherches sur le cancer 02/2007; 172:5-24. DOI: 10.1007/978-3-540-31209-3_2
Source: PubMed

ABSTRACT Tumorigenesis is a multistep process whereby an individual cell acquires a series of mutant gene products. These genetic changes
culminate in proliferation, growth, blocked differentiation, induction of angiogenesis, tissue invasion, and loss of genomic
stability. Given the genetic complexity of tumorigenesis, it is perhaps surprising that there are circumstances in which cancer
can be reversed through the repair or inactivation of individual mutant genes. However, recent experiments in transgenic mouse
models and clinical results with new pharmacological agents demonstrate that cancer can be treated through the targeted repair
and/or inactivation of mutant proteins. Hence, cancers appear to be dependent upon particular oncogenes to maintain their
neoplastic properties, thus exhibiting the phenomenon of “oncogene addiction.”

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