Article

Tuberculosis in acute leukemia: a clinico-hematological profile.

Department of Hematology, AIIMS, New Delhi, India.
Hematology (Amsterdam, Netherlands) (impact factor: 1.33). 11/2006; 11(5):335-40. DOI:10.1080/10245330600915818 pp.335-40
Source: PubMed

ABSTRACT We studied 130 consecutive cases of acute leukemia over a 2-year period and identified 9 cases (6.9%) with active tuberculosis (TB). Eight patients with TB had acute myeloid leukemia (AML). Patients with AML were more likely to develop TB as compared to patients with acute lymphoblastic leukemia (ALL) despite the wider use of steroids and radiotherapy in ALL protocols {OR 4.41 (CI 0.53-36.44)}. Only 1 patient died of disseminated TB during post induction neutropenia. All other patients were successfully managed using current anti-tuberculous therapy (ATT). On the whole, TB did not cause any undue delay in chemotherapy and did not flare up during subsequent chemotherapy cycles. However it is not a commonly described infection in acute leukemia and a high index of suspicion is warranted especially in areas endemic for TB.

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Keywords

130 consecutive cases
 
9 cases
 
acute leukemia
 
acute lymphoblastic leukemia
 
AML
 
areas endemic
 
chemotherapy
 
current anti-tuberculous therapy
 
described infection
 
disseminated TB
 
patients
 
radiotherapy
 
steroids
 
subsequent chemotherapy cycles
 
undue delay
 
wider use