Early physiotherapy after injection of botulinum toxin (Bt) increases the beneficial effects on spasticity in patients with multiple sclerosis

Sapienza University of Rome, Roma, Latium, Italy
Clinical Rehabilitation (Impact Factor: 2.24). 05/2007; 21(4):331-7. DOI: 10.1177/0269215507072772
Source: PubMed

ABSTRACT To determine whether additional physiotherapy increases botulinum toxin type A effects in reducing spasticity in patients with multiple sclerosis.
A single-blind, randomized, controlled pilot trial with a 12-week study period.
Thirty-eight patients with progressive multiple sclerosis affected by focal spasticity and who were observed at the Multiple Sclerosis Centre operating in the S. Andrea Hospital in Rome.
For intervention all patients received botulinum toxin type A; the treatment group also received additional physiotherapy to optimize management through passive or active exercise and stretching regimens.
To measure objective and subjective level of spasticity, patients were assessed at baseline, 2, 4 and 12 weeks post treatment by Modified Ashworth Scale and visual analogue scale.
When compared with the control group, we found a significant decrease of spasticity by Modified Ashworth Scale (P < 0.01 by t-test) in the treatment group at week 2 (2.73 versus 3.22), week 4 (2.64 versus 3.33) and week 12 (2.68 versus 3.33). The mean (%) difference in Modified Ashworth Scale score between baseline and the end of follow-up was -0.95 (26.1) in the treatment group and -0.28 (7.7) in the control group (P < 0.01). The combined treatment proved also to be more effective by visual analogue scale (P < 0.01) at week 4 (6.95 versus 5.50) and at week 12 (7.86 versus 6.56) but not at week 2 (5.18 versus 5.50; P = 0.41).
Our data suggest that physiotherapy in combination with botulinum toxin type A injection can improve overall response to botulinum toxin.

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    • "Physiotherapy for the relief of spasticity in MS (Giovannelli et al 2007; Pöllmann and Feneberg 2008), has not been extensively studied, despite being the standard approach, is insuffi cient alone for most patients, thus antispastic drugs are required. Among these antispastic drugs, the most commonly used are tizanidine and baclofen. "
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