Relation of Body Mass Index and Waist-to-Height Ratio to Cardiovascular Disease Risk Factors in Children and Adolescents: The Bogalusa Heart Study

Divisions of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, GA, USA.
American Journal of Clinical Nutrition (Impact Factor: 6.77). 08/2007; 86(1):33-40.
Source: PubMed


Several investigators have concluded that the waist-to-height ratio is more strongly associated with cardiovascular disease risk factors than is the body mass index (BMI; in kg/m(2)).
We examined the relation of the BMI-for-age z score and waist-to-height ratio to risk factors (lipids, fasting insulin, and blood pressures). We also compared the abilities of these 2 indexes to identify children with adverse risk factors.
Children aged 5-17 y (n=2498) in the Bogalusa Heart Study were evaluated.
As assessed by the ability of the 2 indexes to 1) account for the variability in each risk factor and 2) correctly identify children with adverse values, the predictive abilities of the BMI-for-age z score and waist-to-height ratio were similar. Waist-to-height ratio was slightly better (0.01-0.02 higher R(2) values, P<0.05) in predicting concentrations of total-to-HDL cholesterol ratio and LDL cholesterol, but BMI was slightly better in identifying children with high systolic blood pressure (0.03 higher R(2), P<0.05) in predicting measures of fasting insulin and systolic and diastolic blood pressures. On the basis of an overall index of the 6 risk factors, no difference was observed in the predictive abilities of BMI-for-age and waist-to-height ratio, with areas under the curves of 0.85 and 0.86 (P=0.30) and multiple R(2) values of 0.320 and 0.318 (P=0.79). This similarity likely results from the high intercorrelation (R(2)=0.78) between the 2 indexes.
BMI-for-age and waist-to-height ratio do not differ in their abilities to identify children with adverse risk factors. Although waist-to-height ratio may be preferred because of its simplicity, additional longitudinal data are needed to examine its relation to disease.

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    • "Participants of these studies had diabetes of unknown duration [18]. This makes it difficult to distinguish between the role of weight loss as an innocent bystander reflecting poorly controlled diabetes or as a mediator effectuating the impact of diabetes on death or as an independent risk factor [19]. To deal with this limitation, Carnethon et al. have conducted a study on a sample of participant with newly diagnosed diabetes to examine all-cause, cardiovascular, and noncardiovascular mortality. "
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    PLoS ONE 08/2013; 8(8):e71133. DOI:10.1371/journal.pone.0071133 · 3.23 Impact Factor
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