Surgical intervention that improves pancreatic ductal drainage is a reasonable treatment strategy for recurrent pancreatitis in children.
This study was approved by the Committee on Human Research (San Francisco, CA). A retrospective chart review was performed on children aged 0 to 17 years given the International Classification of Diseases, Ninth Revision coding diagnosis of chronic pancreatitis who underwent surgical intervention from 1981 to 2005.
From 1981 to 2005, 32 children were treated for the diagnosis of chronic pancreatitis. The etiologies were obstructive (n = 13), idiopathic (n = 10), hereditary (n = 6), medications (n = 2), and infection (n = 1). Fifteen patients underwent 17 operations for chronic pancreatitis, including Puestow (n = 9), cystenterostomy (n = 2), Whipple (n = 1), distal pancreatectomy (n = 1), Frey (n = 1), DuVal (n = 1), excision of enteric duplication cyst (n = 1), and pancreatic ductal dilation (n = 1). The mean age at presentation of patients undergoing surgery was 6.0 +/- 4.1 years (mean +/- SD). The mean time from presentation to operation was 3.3 +/- 3.3 years. There were no deaths after surgical intervention. Of 15 patients, 2 (13%) required rehospitalization within 90 days of surgery, one for bowel obstruction, the other for splenic infarction. The median length of stay postoperatively was 8 days (range, 5-66 days).
Chronic pancreatitis in children differs markedly in etiology when compared with adults. In most cases seen in our institution, chronic pancreatitis resulted from ineffective ductal drainage. These disorders are amenable to surgical decompression, which, ultimately, can prevent disease recurrence.
"Fifteen of the patients were treated with pancreatic resection at an average of three years after the presentation but no data was presented about the pathology.  Successful treatment of fibrosing pancreatitis with steroids in three children was described by El-Matary et al. Biopsy of one showed lymphocytic and plasma cell infiltration. "
[Show abstract][Hide abstract] ABSTRACT: In childhood and adolescence, pancreatic neoplasms are generally treated by resection, whereas the management of pancreatitis is predominantly nonoperative. Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis that frequently presents as a mass and responds to corticosteroids. When serologic tests are not diagnostic, a biopsy may spare a child a pancreatic resection. We report the case of a child who presented with a 3 cm mass in the head of the pancreas with a double duct sign who had AIP.
Journal of Pediatric Surgery Case Reports 01/2015; 47(3). DOI:10.1016/j.epsc.2015.01.008
[Show abstract][Hide abstract] ABSTRACT: Hereditary pancreatitis is a clinical condition in which typical pancreatitis is associated with an inheritance pattern strongly suggestive of an autosomal dominant trait. Different variants have been described, some with aminoaciduria and some with ductal anomalies. Recurrent attacks are typical and lead to complications more often than in the idiopathic variety. Pancreatic enzyme supplements or antioxidants may help reduce the frequency and/or severity of attacks.
Gastroenterology Clinics of North America 01/1995; 23(4):743-52. DOI:10.1016/S0025-7125(05)70237-6 · 2.82 Impact Factor
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