Pretreatment of curcumin attenuates coagulopathy and renal injury in LPS-induced endotoxemia

Department of Microbiology, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung City, Taiwan.
Journal of Endotoxin Research (Impact Factor: 3.06). 02/2007; 13(1):15-23. DOI: 10.1177/0968051907078605
Source: PubMed


Disseminated intravascular coagulation (DIC) is a lethal situation in severe infections, characterized by the systemic formation of microthrombi complicated with bleeding tendency and organ dysfunction. Current clinical trials are not promising. In this study, we investigated the protective effect of curcumin in a lipopolysaccharide (LPS)-induced DIC model in rats. Experimental DIC was induced by sustained infusion of LPS (10 mg/kg body weight) for 4 h through the tail vein. Curcumin (60 mg/kg body weight) was given intraperitoneally 3 h before LPS infusion. Results showed that, in vivo, curcumin reduced the mortality rate of LPS-infused rats by decreasing the circulating TNF-alpha levels and the consumption of peripheral platelets and plasma fibrinogen. Furthermore, in vivo curcumin also has the effect of preventing the formation of fibrin deposition in the glomeruli of kidney. These results reveal the therapeutic potential of curcumin in infection-related coagulopathy of DIC.

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    • "• Decreased the expression of TNF-a and reduced the mortality in rat model of sepsis (Siddiqui et al., 2006). • Reduced the mortality rate of LPS-infused rats by decreasing the circulating TNF-a levels and the consumption of peripheral platelets and plasma fibrinogen (Chen et al., 2007). • Significantly inhibited TNF-a and NO levels in rat model of diabetic neuropathy (Sharma et al., 2007b). "
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