Meningococcal Vaccines

Department of Infectious Diseases and Microbiology, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Current pharmaceutical design (Impact Factor: 3.45). 02/2007; 13(19):2009-14. DOI: 10.2174/138161207781039850
Source: PubMed


Neisseria meningitidis is a major world-wide cause of meningitis. N. meningitidis related diseases have become more pronounced in the last decade and changes in meningococcal-associated disease have opened new opportunities for prevention and vaccine development. Although multivalent vaccines have been developed against the N. meningitidis serogroups A, C, W-135, and Y, four of the most common serogroups, the diversity of N. meningitidis has increased the number of challenges for the development of an effective vaccine against all currently identified strains. Without the development of a vaccine against serogroup B, it will be difficult to effectively prevent global meningococcal disease. This review provides a background on N. meningitidis biology and focuses on the current status of meningococcal research and vaccine development. In addition, the efficacy of the currently marketed N. meningitidis vaccines will be discussed.

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    • "However, the value of polysaccharide vaccines is limited as they do not induce immunologic memory and have limited effectiveness in children <5 years of age, leaving this particularly vulnerable age group unprotected [4] [5]. In addition , MPSV4s do not induce herd immunity and have been found to invoke hyporesponsiveness following subsequent immunization with either MPSV4 or meningococcal conjugate vaccines [6] [7] [8] [9]. Until recently, one MPSV4 (Menomune ® ; sanofi pasteur, Swiftwater , Pennsylvania, USA) was the only quadrivalent vaccine available in the USA to protect against serogroups A, C, W-135, and Y. "
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