[Show abstract][Hide abstract] ABSTRACT: The light microscopic histopathology and cytopathology of papillary thyroid carcinoma (PTC) and its variants is amply depicted in reviews, books, and book chapters. One of the changes in PTC, however, that is infrequently discussed or illustrated in the literature is that of mucinous metaplasia. In the aspiration cytopathology literature, we are aware of only a rare report of PTC exhibiting extensive mucinous metaplasia. We present an example correlating the histopathology and fine needle aspiration cytopathology of a PTC that had metastasized on several separate occasions to cervical lymph nodes, and in the process demonstrated mucinous transformation. Without a prior history of PTC, the aspirate smears and tissue sections could have been mistaken easily for metastatic clear cell carcinoma of non-thyroidal origin. Mucinous metaplasia represents an extremely uncommon, but nonetheless potential, pitfall in the aspiration cytopathology and histopathology of metastatic PTC.
Modern Pathology 05/2001; 14(4):361-5. DOI:10.1038/modpathol.3880316 · 6.19 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: From 1946 through 1982, 30 cases of distant malignant disease that metastasized to the thyroid were diagnosed at the Mayo Clinic. Although metastatic thyroid lesions are not uncommon, they generally do not pose a problem because they are small or are associated with evidence of obvious widespread metastatic disease. The most common sources of such lesions are the kidney, breast, lung, and lymphoid tissue. The thyroid metastatic lesion may appear many years after the identification and treatment of the primary cancer. Because the thyroid lesion may be the only important malignant disease remaining, adequate surgical treatment may prove to be life-prolonging or life-saving.
Mayo Clinic Proceedings 01/1985; 59(12):856-9. DOI:10.1016/S0025-6196(12)65622-5 · 6.26 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: A mucin-producing carcinoma in the thyroid gland found in a 44-year-old man was first thought to be a metastatic carcinoma, possibly from salivary gland. However, follow-up examinations for 8 years have not demonstrated another neoplasm, and it seems reasonable to conclude that this lesion was a rare primary mucinous adenocarcinoma of the thyroid gland.
Cancer 10/1976; 38(3):1323-5. · 4.89 Impact Factor
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