Brief Report: Abnormal Association Between the Thalamus and Brain Size in Asperger’s Disorder
ABSTRACT The objective of this study was to examine the relationship between thalamic volume and brain size in individuals with Asperger's disorder (ASP). Volumetric measurements of the thalamus were performed on MRI scans obtained from 12 individuals with ASP (age range: 10-35 years) and 12 healthy controls (age range: 9-33 years). A positive correlation was found between total brain volume and thalamic size in controls, but not in ASP subjects. This occurred in the absence of differences in mean thalamic volumes between the study groups. Findings from this investigation point to an abnormal relationship between the thalamus and its projection areas in ASP and are consistent with similar studies in autism, supporting that these disorders are qualitatively similar and possibly quantitatively different.
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- "In the literature, theta synchronization relating with recognition of stimuli reflects the activity in thalamus-cortical and hippocampal-cortical circuits . Our findings support the hypothesis that both circuits might contain some functional disorders in participants with AS . Besides, emotion-related theta synchronization is connected with activity of the amygdale . "
ABSTRACT: EEG reactions in emotional face recognition were studied in five participants with Asperger syndrome (AS) and seven control subjects. Control subjects showed a spectral power increase following the stimulus onset in two time-frequency intervals-(1) 150-300ms in the 1-16Hz frequency range and (2) 300-650ms in the 1-8Hz range. Also, alpha/beta desynchronization occurred 400-1000ms after the stimulus onset with maximal amplitude in the posterior region. Theta synchronization (4-8Hz) was weaker in the AS group than in the control group, but beta2 desynchronization was stronger in the AS group. The results were interpreted in terms of automatic and voluntary control of perception.Neuroscience Letters 04/2011; 492(2):84-8. DOI:10.1016/j.neulet.2011.01.061 · 2.06 Impact Factor
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ABSTRACT: It is pointed out that the Nelder-Mead simplex method rescaling and shrinking steps make it sensitive to random variations in the response function values, and introduce risks of false convergence on stochastic functions. The authors give analytical and empirical evidence that characterizes false convergence on stochastic functions, and discuss several modifications to reduce the likelihood of false convergence. They describe a computational comparison of several modifications when used to optimize simple stochastic functions of two and ten variablesProceedings of the 23th Winter Simulation Conference, Phoenix, Arizona, USA, December 8-11, 1991; 01/1991
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ABSTRACT: To determine whether Oxiplex/AP Gel (FzioMed, San Luis Obispo, CA) was safe and preliminarily effective in reducing postsurgical adhesions after adnexal surgery by laparoscopy. Prospective, multicenter, double-blind, randomized, U.S. Food and Drug Administration-monitored feasibility study. University and private clinics. Patients undergoing laparoscopic surgery with pelvic adhesions, tubal occlusion, endometriosis, and/or dermoids were randomized to receive Oxiplex/AP Gel or no further treatment after surgery. A blinded, parallel-group design was conducted at six centers. Patients (aged 18-46 years) underwent laparoscopic surgery, with second-look surgery 6-10 weeks later. Surgeries were videotaped. Oxiplex/AP Gel was used to cover adnexa and adjacent tissue. Blinded reviews of videotapes were quantitated with the American Fertility Society adhesion score (AFS score). In 18 treatment patients, surgery was performed on 29 adnexa. Application of Oxiplex/AP Gel required approximately 90 seconds. In 10 control patients, surgery was performed on 18 adnexa. The mean baseline AFS score for each group was 8.0. At second look, treated adnexa had the same score (8.1), whereas in control adnexa the score increased (from 8.0 to 11.6). Thirty-four percent of treated adnexa increased in adhesion score, in contrast to 67% of control adnexa. There were no device-related adverse events. In this pilot study, Oxiplex/AP Gel was safe, easy to use with laparoscopy, and produced a reduction in the increase of adnexal adhesion scores.Fertility and sterility 12/2005; 84(5):1450-6. DOI:10.1016/j.fertnstert.2005.04.055 · 4.59 Impact Factor