Article

A retrospective and comparative study of familial and non-familial bullous lichen planus.

Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.
Journal of Huazhong University of Science and Technology (impact factor: 0.38). 07/2007; 27(3):336-8. DOI:10.1007/s11596-007-0331-7 pp.336-8
Source: PubMed

ABSTRACT In order to compare the clinical characteristics of familial and non-familial bullous lichen planus (BLP), the archival data of 36 BLP patients with positive family history and 21 BLP patients with negative family history diagnosed according to the clinical features and histopathology were collected in our department from 1956 to 2003. The clinical features were analyzed and compared. There were significant differences between familial and non-familial BLP in age of onset, duration of disease and extension of eruption (P<0.01). It was concluded that familial BLP appeared to differ from the non-familial form in its earlier age of onset, longer duration of the disease, more extensive eruption and more tendency to involve nails. Hereditary factors may play a role in the pathogenesis of familial BLP.

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Keywords

21 BLP patients
 
36 BLP patients
 
archival data
 
clinical characteristics
 
clinical features
 
eruption
 
extensive eruption
 
familial
 
familial BLP
 
Hereditary factors
 
non-familial BLP
 
non-familial bullous lichen planus
 
non-familial form
 
positive family history