Staples, Tape Measures, and Bungee Cords: A Variety of Bifunctional Reagents for Understanding and Controlling Ion Channels

Department of Molecular and Cell Biology , University of California, Berkeley, Berkeley, California, United States
ACS Chemical Biology (Impact Factor: 5.33). 08/2007; 2(7):451-3. DOI: 10.1021/cb700135a
Source: PubMed


Chemical modification of proteins with bifunctional reagents has become a widely used technique for analyzing protein structure and dynamics. A new era is emerging, and scientists can now actually control the function of proteins by tethering molecular switches at a desired position. In a new paper, researchers stretch the technique a bit further by using a reactive derivative of a peptide toxin to probe the subunit composition of a voltage-gated K+ channel.

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