Defined reprogramming: a vehicle for changing the differentiated state

Department of Molecular and Cellular Biology, Stowers Medical Institute and Harvard Medical Institute, Harvard University, 7 Divinity Avenue, Cambridge, MA 02138, USA.
Differentiation (Impact Factor: 2.84). 10/2007; 75(7):577-9. DOI: 10.1111/j.1432-0436.2007.00213.x
Source: PubMed
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    ABSTRACT: ABSTRACT In the past one and half years scientific community,and general public have been excited with the discovery of induced pluripotent stem (iPS) cells. However, how much truth is contained in the various claims made for iPS cells? What are these iPS cells? Are they really safe for therapeutic use? This review attempts to present a balanced view on iPS cells so that their pros and cons can be better understood. KEY WORDS Stem cells, iPS cells, Induction, Reprogramming, Repetition, Evidence, Control, Mistake, Criticism, Truth The hottest cells in town now are iPS cells – the so- called induced pluripotent stem cells. These cells
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    ABSTRACT: Stem cell research plays an important role in orthopedic regenerative medicine today. Current literature provides us with promising results from animal research in the fields of bone, tendon, and cartilage repair. While early clinical results are already published for bone and cartilage repair, the data about tendon repair is limited to animal studies. The success of these techniques remains inconsistent in all three mentioned areas. This may be due to different application techniques varying from simple mesenchymal stem cell injection up to complex tissue engineering. However, the ideal carrier for the stem cells still remains controversial. This paper aims to provide a better understanding of current basic research and clinical data concerning stem cell research in bone, tendon, and cartilage repair. Furthermore, a focus is set on different stem cell application techniques in tendon reconstruction, cartilage repair, and filling of bone defects.
    02/2012; 2012:394962. DOI:10.1155/2012/394962
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    ABSTRACT: HIGHLIGHT No biological research has captured so much and so intense attention from the "top" journals. The heavy spinning on iPS cells has created a global hype on "therapeutic" cloning and regenerative "medicine". ABSTRACT Science should progress on solid testing of the hypotheses and independent validation of the claims. However, nowadays many anticipated "discoveries" are "confirmed" by heavy spinning and massive broadcasting. The "generation" of so-called "induced" pluripotent stem (iPS) cells actually has never been proven beyond reasonable doubt. However, "top" journals still spun heavily on this unproven claim while totally suppressing objective criticisms ( Some of the "experts' Commentaries are outright misrepresentations. Unfortunately, these untruthful abstractions made into headlines of mass media that led to the hypes of "turning clock back" and "turning lead into gold". However, history will quickly show that the so-called "first biological airplane" will never fly over the therapeutic cloning "sky" and a Nobel-Prize-"winning" discovery is a great detour in stem cell research.

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