Article

Hypocholesterolemic and antioxidant properties of 3-(4-hydroxyl)propanoic acid derivatives in high-cholesterol fed rats.

Department of Food and Nutrition, Sunchon National University, Jeonnam, Republic of Korea.
Chemico-Biological Interactions (Impact Factor: 2.98). 11/2007; 170(1):9-19. DOI: 10.1016/j.cbi.2007.06.037
Source: PubMed

ABSTRACT The purpose of the present study was to evaluate the in vivo efficacy of two cinnamic acid synthetic derivatives (allyl 3-[4-hydroxyphenyl]propanoate; HPP304, 1-naphthyl-methyl 3-[4-hydroxyphenyl]propanoate; HPP305) in high-cholesterol fed rats and compare their actions to that of cinnamic acid. Cinnamic acid and its synthetic derivatives were supplemented with a high-cholesterol diet for 42 days at a dose of 0.135 mmol/100g of diet. The supplementation of HPP304 and HPP305 significantly lowered cholesterol and triglyceride levels in the plasma and liver with a simultaneous increase in the HDL-cholesterol concentration, whereas cinnamic acid only lowered the plasma cholesterol concentration. Cinnamic acid lowered hepatic HMG-CoA reductase activity in high-cholesterol fed rats, however, its synthetic derivatives (HPP304 and HPP305) did not affect HMG-CoA reductase activity compared to the control group. Instead, the HPP304 and HPP305 supplements significantly lowered hepatic acyl coenzyme A:cholesterol acyltransferase activity and increased the fecal bile acid. The SOD activity of the erythrocytes and liver was not different between the groups, however, the activities of CAT and GSH-Px, and the level of GSH in the erythrocytes were significantly higher in the HPP304 and HPP305 groups than in the control group. On the other hand, the activities of CAT and GSH-Px, and the level of malondialdehyde in the liver were significantly lower in the HPP304 and HPP305 groups. The antioxidant activities of these cinnamic acid synthetic derivatives were similar to the cinnamic acid in the high-cholesterol fed rats. In addition, HPP304 and HPP305 lowered amniotransferase activity in the plasma. These results suggest that two cinnamic acid synthetic derivatives (HPP304 and HPP305) exert lipid-lowering action and antioxidant properties without hepatotoxicity in high-cholesterol fed rats.

0 Bookmarks
 · 
73 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Hypercholesterolemia-induced oxidative stress has been strongly implicated in the pathogenesis of atherosclerosis, which is one of the major causes of mortality worldwide. The current work, for the first time, accounts the antioxidant, genoprotective, antilipoperoxidative, and HMG-CoA reductase (EC 1.1.1.34) inhibitory properties of traditional medicinal plant, Ficus palmata Forsk. Our result showed that among sequentially extracted fractions of Ficus palmata Forsk, FPBA (F. palmata bark aqueous extract) and FPLM (F. palmata leaves methanolic extract) extracts have higher phenolic content and also exhibited significantly more radical scavenging (DPPH and Superoxide) and antioxidant (FRAP) capacity. Moreover, FPBA extract also exhibited significantly higher inhibition of lipid peroxidation assay. Additionally, results showed almost complete and partial protection of oxidatively damaged DNA by these plant extracts when compared to mannitol. Furthermore, our results showed that FPBA extract (IC50 = 9.1 ± 0.61 µg/mL) exhibited noteworthy inhibition of HMG-CoA reductase activity as compared to other extracts, which might suggest its role as cardioprotective agent. In conclusion, results showed that FPBA extract not only possess significant antioxidant and genoprotective property but also is able to attenuate the enzymatic activity of HMG-CoA reductase, which might suggest its role in combating various oxidative stress-related diseases, including atherosclerosis.
    BioMed Research International 01/2014; 2014:762620. · 2.71 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: A variety of natural vinegar products are found in civilizations around the world. A review of research on these fermented products indicates numerous reports of health benefits derived by consumption of vinegar components. Therapeutic effects of vinegar arising from consuming the inherent bioactive components including acetic acid, gallic acid, catechin, ephicatechin, chlorogenic acid, caffeic acid, p-coumaric acid, and ferulic acid cause antioxidative, antidiabetic, antimicrobial, antitumor, antiobesity, antihypertensive, and cholesterol-lowering responses. The aims of this article are to discuss vinegar history, production, varieties, acetic acid bacteria, and functional properties of vinegars.
    Journal of Food Science 05/2014; 79(5). · 1.78 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Dalkilic, B., Ciftci, M., Guler, T., Cerci, I.H., Ertas, O.N. and Guvenc, M. 2009. Influence of dietary cinnamon oil supplementation on fatty acid composition of liver and abdominal fat in broiler chicken. J. Appl. Anim. Res., 35: 173–176.The potential effects of essential oil from cinnamon on fatty acid compositions of liver and abdominal fat in broilers were studied. Two hundred and forty 5-d-old commercial broiler chicks (Ross–308) were divided into 4 equal groups of 60 birds in each and randomly assigned to four treatment diets with four replicates. Experimental groups were; corn-soybean meal basal diet (Control), basal diet supplemented with 10 mg/kg Avilamycin (Antibiotic), 500 or 1000 ppm of cinnamon oil (C500, C1000). Poly unsaturated fatty acid (PUFA), omega-3 and omega-6 fatty acid levels of liver lipids were found higher but saturated fatty acid (SFA) levels were found lower in cinnamon oil added groups. The lowest mono unsaturated fatty acid (MUFA) level and the highest SFA level of abdominal fat were found in control group. Supplementation of cinnamon oil to diets could be considered as a natural alternative for producing poultry meat with more desirable PUFA.
    Journal of Applied Animal Research 06/2009; 35(2):173-176. · 0.48 Impact Factor