Impact of empirical-therapy selection on outcomes of intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus.

Albany College of Pharmacy, Albany, NY 12208-3492, USA.
Antimicrobial Agents and Chemotherapy (Impact Factor: 4.45). 11/2007; 51(10):3731-3. DOI: 10.1128/AAC.00101-07
Source: PubMed

ABSTRACT This study compares beta-lactam and vancomycin among intravenous drug users with infective endocarditis caused by methicillin-susceptible Staphylococcus aureus. Patients who received vancomycin had higher infection-related mortality, even if they were switched to beta-lactam once culture results became available; this relationship persisted after logistic regression analysis controlling for clinical characteristics.

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