Tourette Syndrome and Tic Disorders: A Decade of Progress

Child Study Center of Yale University, New Haven, CT, USA.
Journal of the American Academy of Child & Adolescent Psychiatry (Impact Factor: 7.26). 09/2007; 46(8):947-68. DOI: 10.1097/chi.0b013e318068fbcc
Source: PubMed

ABSTRACT This is a review of progress made in the understanding of Tourette syndrome (TS) during the past decade including models of pathogenesis, state-of-the-art assessment techniques, and treatment.
Computerized literature searches were conducted under the key words "Tourette syndrome," "Tourette disorder," and "tics." Only references from 1996-2006 were included.
Studies have documented the natural history of TS and the finding that tics usually improve by the end of the second decade of life. It has also become clear that TS frequently co-occurs with attention-deficit/hyperactivity disorder), obsessive-compulsive disorder, and a range of other mood and anxiety disorders. These comorbid conditions are often the major source of impairment for the affected child. Advances have also been made in understanding the underlying neurobiology of TS using in vivo neuroimaging and neurophysiology techniques. Progress on the genetic front has been less rapid. Proper diagnosis and education (involving the affected child and his or her parents, teachers, and peers) are essential prerequisites to the successful management of children with TS. When necessary, modestly effective antitic medications are available, although intervening to treat the comorbid attention-deficit/hyperactivity disorder and/or obsessive-compulsive disorder is usually the place to start.
Prospective longitudinal studies and randomized clinical trials have led to the refinement of several models of pathogenesis and advanced our evidence base regarding treatment options. However, fully explanatory models are needed that would allow for more accurate prognosis and the development of targeted and efficacious treatments.

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Available from: James E Swain, Sep 29, 2015
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    • "The onset of TD occurs in childhood and the prevalence is higher in males than in females (4.3: 1) [1,2]. Of school-aged children, 6%–20% experience transient tics and 0.5%–1% suffer from chronic tics or TD [3]. TD usually has a familial component [2]. "
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    ABSTRACT: A subgroup of patients with Tourette's disorder (TD) has symptoms refractory to haloperidol, a standard therapeutic drug for TD. We report on three cases of pediatric and adolescent patients who were treated with paliperidone extended release. In two cases, TD symptoms were remarkably improved by switching from haloperidol to paliperidone extended release, and in another case, paliperidone extended release showed significant efficacy in treating TD symptoms as the first-line drug. In all cases, no significant adverse side effects were detected. Paliperidone extended release may be a strong candidate for the treatment of pediatric and adolescent patients with TD.
    Annals of General Psychiatry 05/2014; 13(1):13. DOI:10.1186/1744-859X-13-13 · 1.40 Impact Factor
    • "Children with ADHD may also present with comorbid tic disorders or Tourette syndrome (TS). It is estimated that 60–70% of children with TS will also meet diagnostic criteria for ADHD (Swain et al. 2007). The presence of tics can complicate treatment planning because of concerns that pharmacological treatment can exacerbate tic symptoms. "
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    ABSTRACT: Attention-deficit hyperactivity disorder (ADHD) is a complex disorder that can affect individuals across the lifespan. It is associated with substantial heterogeneity in terms of aetiology, clinical presentation and treatment outcome and is the subject of extensive research. Because of this, it can be difficult for clinicians to stay up to date with the most relevant findings and know how best to respond to parents' questions and concerns about the disorder and interventions. This is a narrative review that aims to summarize key findings from recent research into ADHD and its treatment that clinicians can share with families in order to increase their knowledge about ADHD and intervention options. ADHD develops as a result of complex interplay between interdependent genetic and non-genetic factors. The disorder is associated with substantial impairments in functioning and poor long-term outcomes. Pharmacological and non-pharmacological treatment options are available for symptom management and to improve function, but functioning outcomes often fail to normalize in children with ADHD. Despite extensive advances in understanding this complex disorder, it is clear that there is still a long way to go. In particular, we address the need for future non-pharmacological interventions to be more specifically targeted for ADHD symptoms and its commonly associated functioning deficits in order to ensure the best long-term outcomes for children with ADHD.
    Child Care Health and Development 05/2014; 40(6). DOI:10.1111/cch.12139 · 1.69 Impact Factor
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    • "The pathology is characterized by the presence of tics, which are rapid, stereotyped movements and vocalizations, virtually involving all body segments (Vicario et al., 2010). The neuro-functional profile of childhood TS is characterized by impairment of neural circuits linking the cerebral cortex to the striatum and other sub-cortical regions (Swain et al., 2007; Bush, 2011). "
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    ABSTRACT: In the last decades interest in application of non-invasive brain stimulation for enhancing neural functions is growing continuously. However, the use of such techniques in pediatric populations remains rather limited and mainly confined to the treatment of severe neurological and psychiatric diseases. In this article we provide a complete review of non-invasive brain stimulation studies conducted in pediatric populations. We also provide a brief discussion about the current limitations and future directions in a field of research still very young and full of issues to be explored.
    Frontiers in Systems Neuroscience 11/2013; 7:94. DOI:10.3389/fnsys.2013.00094
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