Article

The application of exposure therapy and D-cycloserine to the treatment of anorexia nervosa: a preliminary trial.

College of Physicians & Surgeons of Columbia University, New York, NY 10032, USA.
Journal of Psychiatric Practice (Impact Factor: 1.35). 08/2007; 13(4):238-45. DOI: 10.1097/01.pra.0000281484.89075.a8
Source: PubMed

ABSTRACT Novel approaches to the treatment of anorexia nervosa (AN) are needed. This preliminary study examined the utility and safety of an exposure therapy intervention and D-cycloserine (DCS) in a population of patients with AN.
Eleven participants completed a series of 6 laboratory meals, including pre- and post-exposure test meals and four exposure sessions. Participants were randomly assigned to receive either DCS or placebo in double-blind fashion before each of the 4 exposure sessions. These results were compared to data from a previously studied group of patients who received treatment as usual.
Total caloric intake increased significantly from the baseline meal session to the post-test meal session in the patients who received the exposure therapy intervention. Caloric intake did not increase significantly in the comparison group.
These data suggest that an exposure therapy intervention specifically focused on meal consumption may be helpful in increasing intake of a test meal.

Full-text

Available from: Janet Schebendach, Oct 08, 2014
0 Bookmarks
 · 
80 Views
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: This literature review aims to discern patterns among empirical research regarding the association between distance running and disordered eating among females. The findings show that female distance runners share certain characteristics with eating disordered non-athletes, such as low BMI, perfectionist tendencies, and menstrual dysfunction. These characteristics, indicative of disordered eating among non-athletic females, do not indicate a similar risk among runners. These findings suggest that perfectionism may be channeled more healthily through exercise than through disordered eating, and that low BMI and menstrual dysfunction among distance runners can appear in the absence of disordered eating.
  • Source
    [Show abstract] [Hide abstract]
    ABSTRACT: Fear extinction learning, the ability to reassess a learned cue of danger as safe when it no longer predicts aversive events, is often dysregulated in anxiety disorders. Selective serotonin reuptake inhibitors (SSRI's) enhance neural plasticity and their ability to enhance fear extinction learning may explain their anxiolytic properties. Caloric restriction (CR) has SSRI-like effects on neural plasticity and anxiety-related behavior. We implemented CR in mice to determine its effects on conditioned fear responses. Wild type and serotonin transporter (SERT) knockout mice underwent CR for seven days leading to significant weight loss. Mice were then tested for cued fear learning and anxiety-related behavior. CR markedly enhanced fear extinction learning and its retention in adolescent female mice and adults of both sexes. These effects of CR were absent in SERT knockout mice. Moreover, CR phenocopied behavioral and molecular effects of chronic fluoxetine but there was no additive effect of CR in fluoxetine-treated mice. These results demonstrate that CR enhances fear extinction learning through a SERT-dependent mechanism. These results may have implications for eating disorders such as anorexia nervosa (AN), in which there is a high prevalence of anxiety prior to the onset of dietary restriction and support proposals that in AN CR is a motivated effort to control dysregulated fear responses and elevated anxiety.Neuropsychopharmacology accepted article preview online, 3 January 2013; doi:10.1038/npp.2012.268.
    Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology 01/2013; 38(6). DOI:10.1038/npp.2012.268 · 8.68 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Exposure therapy is a widely used and effective form of treatment in anxiety disorders and addictions but evidence for its usefulness in eating disorders (ED) is inconsistent. This paper systematically reviews the literature on the use of exposure therapy in ED, the theory underpinning its use, and the deficits in current knowledge. Databases were searched to 2012. In addition, potential improvements in the use of exposure techniques in ED are considered by drawing upon theory and research involving neuropharmacology, basic and clinical neuroscience, contemporary behavioural and neurobiological research, and technologies such as virtual reality (VR).
    Neuroscience & Biobehavioral Reviews 11/2012; DOI:10.1016/j.neubiorev.2012.11.010 · 10.28 Impact Factor