The proportion of individuals with obesity-induced hypertension among total hypertensives in a general Japanese population: NIPPON DATA80, 90
ABSTRACT The increased prevalence of obesity in Japan may contribute to the high prevalence of hypertension in Japan. In the present study, we calculated the odds ratio for hypertension in obesity (body mass index (BMI) >or= 25.0 kg/m(2)) using data from independent nationwide surveys conducted in 1980 and 1990. We estimated the percentage of hypertensives whose condition was due to obesity among total hypertensives in the general Japanese population. In the 1980 survey, 18.8% of 4,623 male participants were obese and 50.4% were hypertensive, whereas 22.6% of 5,893 female participants were obese and 41.1% were hypertensive. For both sexes, obese participants had a higher odds ratio for hypertension than non-obese participants (BMI < 25.0 kg/m(2)), and there was a significant dose-response relationship between BMI and the odds ratio for hypertension. Among all hypertensives, the percentage whose hypertension was due to obesity in 1980 and 1990 was 11.4% (95% confidence interval (CI): 4.7-17.7%) and 15.3% (95% CI: 6.8-23.1%) for men and 19.3% (95% CI: 12.1-25.9%) and 22.3% (95% CI: 14.6-29.3%) for women, respectively. Approximately 80-90% of individuals with obesity-induced hypertension were in the 25.0 <or= BMI < 30.0 kg/m(2) category for both sexes in each year. In conclusion, we found that obesity-induced hypertension as a proportion of total hypertension increased between 1980 and 1990 for both sexes. Obesity now is playing a more important role in the high prevalence of hypertension in Japan than it was before.
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ABSTRACT: Although abdominal obesity (AO) assessed by waist circumference (WC) is an important component of the metabolic syndrome (MetS), the usefulness of AO as a predictor of hypertension (HT) is not known. In this study, we investigated the incidence of HT in residents of two rural communities in Japan. The subjects were 187 men and 209 women selected from 712 residents who had undergone medical examinations in the towns of Tanno and Sobetsu, Hokkaido, in 1994 and 2002. Participants with HT in 1994 were excluded. Participants with AO were determined according to the WC criteria in the Japanese definition of MetS (> or = 85 cm for men, > or = 90 cm for women). The participants were divided into two groups: a non-AO group and an AO group. We compared the incidence of HT between the two groups and found a significantly higher incidence in the AO group. The results of logistic regression analysis showed that the relative risk of developing HT in individuals with AO was 2.33 (p = 0.017; 95% confidence interval [CI], 1.17-4.63) and that the risk per 1-cm increase in WC from 1994 to 2002 was 1.06 (p = 0.003; 95% CI, 1.02-1.10), both adjusted for several confounding factors. The results of this study suggest that, to prevent HT in Japanese, it is important to manage abdominal obesity and to monitor WC in individuals with or without abdominal obesity.Hypertension Research 07/2008; 31(7):1385-90. DOI:10.1291/hypres.31.1385 · 2.94 Impact Factor
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ABSTRACT: BACKGROUND: Little is known about the prevalence of bundle branch block (BBB) and its association with other cardiovascular disease (CVD) risk factors in the general population. The present study aims to describe the prevalence and examine this association using data from the US National Health and Nutrition Examination Survey (NHANES-III) and 1990 Japan National Survey on Circulatory Disorders. METHODS: A cross-sectional analytical study design was used in the study with a focus on the differences in the prevalence of left and right BBB (LBBB and RBBB) and their relation to other CVD risk factors between American and Japanese people aged >/=40 years. RESULTS: (1) Age-adjusted prevalences of LBBB per 1000 population were 5.2 and 1.9 for the US and Japan samples (p<0.001). No significant difference in the prevalence of RBBB was observed between the two population samples (25.3 per thousand vs. 24.2 per thousand). (2) LBBB and RBBB were significantly associated with several other CVD risk factors. (3) Multivariate logistic analyses indicated that LBBB and RBBB were significantly associated with increased age, SBP, glomerular filtration rate (GFR), and sex and BMI (for RBBB only) in the US sample. Significant relations of LBBB to age, history of stroke and diabetes; and of RBBB to age, sex, total protein and GFR were observed in the Japanese sample. CONCLUSION: The American sample has significantly higher prevalence of LBBB than the Japanese sample. BBB is strongly associated with several other CVD risk factors, but the strengths of these associations are different between the US and Japan samples.International journal of cardiology 01/2009; 143(3):432-40. DOI:10.1016/j.ijcard.2008.12.022 · 6.18 Impact Factor
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ABSTRACT: We assessed whether single nucleotide polymorphism rs1042615 of the vasopressin V1a receptor altered the indices of lifestyle-related diseases in middle-aged and older people (mean+/-SD: 64+/-7 years), and, if so, whether it also altered the effects of interval walking training (IWT). CC, CT, and TT carriers of rs1042615 (42, 118, and 64 men, respectively; 113, 263, and 154 women, respectively) performed IWT. We included 5 sets of 3-minute fast walking at > or =70% peak aerobic capacity for walking and 3-minute slow walking at 40% peak aerobic capacity per day for > or =4 days per week for 5 months. Before IWT, the body mass index and diastolic blood pressure (DBP) for men were 25.1+/-0.3 kg/m(2) (mean+/-SE) and 84+/-1 mm Hg in TT, higher than the 23.6+/-0.4 kg/m(2) and 78+/-1 mm Hg in CC, respectively (P<0.01), differences that disappeared after IWT despite similar training achievement between groups (P>0.6). After IWT, body mass index and DBP decreased in TT (-0.9+/-0.1 kg/m(2) and -5+/-1 mm Hg, respectively), more than in CC (-0.5+/-0.1 kg/m(2) and 1+/-1 mm Hg, respectively; P<0.05), with a greater decrease in low-density lipoprotein cholesterol in TT than CC carriers (P<0.01). The decreases in DBP and low-density lipoprotein cholesterol were still greater in TT carriers even after adjustment for their pretraining values. On the other hand, for women, these parameters before IWT and their changes after IWT were similar among CC, CT, and TT carriers. Thus, polymorphism rs1042615 of the V1a receptor altered body mass index and DBP in middle-aged and older men and the training-induced responses of DBP and low-density lipoprotein cholesterol, whereas women did not show any of these responses.Hypertension 02/2010; 55(3):747-54. DOI:10.1161/HYPERTENSIONAHA.109.147728 · 7.63 Impact Factor