The proportion of individuals with obesity-induced hypertension among total hypertensives in a general Japanese population: NIPPON DATA80, 90.
ABSTRACT The increased prevalence of obesity in Japan may contribute to the high prevalence of hypertension in Japan. In the present study, we calculated the odds ratio for hypertension in obesity (body mass index (BMI) >or= 25.0 kg/m(2)) using data from independent nationwide surveys conducted in 1980 and 1990. We estimated the percentage of hypertensives whose condition was due to obesity among total hypertensives in the general Japanese population. In the 1980 survey, 18.8% of 4,623 male participants were obese and 50.4% were hypertensive, whereas 22.6% of 5,893 female participants were obese and 41.1% were hypertensive. For both sexes, obese participants had a higher odds ratio for hypertension than non-obese participants (BMI < 25.0 kg/m(2)), and there was a significant dose-response relationship between BMI and the odds ratio for hypertension. Among all hypertensives, the percentage whose hypertension was due to obesity in 1980 and 1990 was 11.4% (95% confidence interval (CI): 4.7-17.7%) and 15.3% (95% CI: 6.8-23.1%) for men and 19.3% (95% CI: 12.1-25.9%) and 22.3% (95% CI: 14.6-29.3%) for women, respectively. Approximately 80-90% of individuals with obesity-induced hypertension were in the 25.0 <or= BMI < 30.0 kg/m(2) category for both sexes in each year. In conclusion, we found that obesity-induced hypertension as a proportion of total hypertension increased between 1980 and 1990 for both sexes. Obesity now is playing a more important role in the high prevalence of hypertension in Japan than it was before.
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ABSTRACT: BACKGROUND: Little is known about the prevalence of bundle branch block (BBB) and its association with other cardiovascular disease (CVD) risk factors in the general population. The present study aims to describe the prevalence and examine this association using data from the US National Health and Nutrition Examination Survey (NHANES-III) and 1990 Japan National Survey on Circulatory Disorders. METHODS: A cross-sectional analytical study design was used in the study with a focus on the differences in the prevalence of left and right BBB (LBBB and RBBB) and their relation to other CVD risk factors between American and Japanese people aged >/=40 years. RESULTS: (1) Age-adjusted prevalences of LBBB per 1000 population were 5.2 and 1.9 for the US and Japan samples (p<0.001). No significant difference in the prevalence of RBBB was observed between the two population samples (25.3 per thousand vs. 24.2 per thousand). (2) LBBB and RBBB were significantly associated with several other CVD risk factors. (3) Multivariate logistic analyses indicated that LBBB and RBBB were significantly associated with increased age, SBP, glomerular filtration rate (GFR), and sex and BMI (for RBBB only) in the US sample. Significant relations of LBBB to age, history of stroke and diabetes; and of RBBB to age, sex, total protein and GFR were observed in the Japanese sample. CONCLUSION: The American sample has significantly higher prevalence of LBBB than the Japanese sample. BBB is strongly associated with several other CVD risk factors, but the strengths of these associations are different between the US and Japan samples.International journal of cardiology 01/2009; 143(3):432-40. · 6.18 Impact Factor
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ABSTRACT: Elevated risk of death from any cause and stroke associated with high body mass index (BMI) values decline with aging. However, it is not clear whether the effect of obesity on the incidence of hypertension varies by sex or age. Cox regression analyses were performed using a large historical cohort composed of 6803 men and 22,800 women. In the final model, which included the main effect (sex, age, and BMI), all two-way interactions (sex*age, sex*BMI, and age*BMI), a three-way interaction (sex*age*BMI), and adjusted variables determined by backward elimination, the three-way interaction and two of the two-way interactions (age*sex and age*BMI) were not significant; the remaining two-way interaction between sex and BMI was significant (P = .016). In the next step, the effect of BMI on the incidence of hypertension stratified by sex was evaluated. Hazard ratios (HRs) were significantly higher for BMI 27.0 to <29.0 and ≥29.0 kg/m(2) than for the HR for BMI 21.0 to <23.0 kg/m(2) in women (HR, 1.45; 95% confidence interval [CI], 1.32-1.59 and HR, 1.46; 95% CI, 1.29-1.65, respectively), but not in men (HR, 1.14; 95% CI, 0.98-1.33 and HR, 1.01; 95% CI, 0.77-1.32, respectively). The effect of obesity on the incidence of hypertension is stronger in women than in men.Journal of the American Society of Hypertension (JASH) 10/2013;
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ABSTRACT: The United States has a higher prevalence of metabolic syndrome (MS) and cardiovascular disease (CVD) mortality than Japan, but it is unknown how much of the difference in MS accounts for the mortality difference. The aim of this study was to examine the impact of MS on the excess CVD mortality in the United States compared with that in Japan. Data from the United States Third National Health and Nutrition Examination Survey (NHANES III; n = 12,561) and the Japanese National Integrated Project for Prospective Observation of Noncommunicable Disease and Its Trends in Aged (NIPPON DATA; n = 7,453) were analyzed. MS was defined as ≥3 of 5 risk factors (obesity, high blood pressure, decreased high-density lipoprotein cholesterol, elevated glycosylated hemoglobin, and elevated triglycerides). The results show that after a median of 13.8 years of follow-up in the United States, 1,683 patients died from CVD (11.75 per 1,000 person-years), and after a median of 15 years of follow-up in Japan, 369 patients died from CVD (3.56 per 1,000 person-years). The age-adjusted prevalence of MS was 26.7% in the United States and 19.3% in Japan. Of 5 MS factors, obesity, high blood pressure, elevated triglycerides, and glycosylated hemoglobin in the United States, and high blood pressure and elevated glycosylated hemoglobin in Japan were significant risk factors for CVD mortality. Estimates of 13.3% and 44% of the excess CVD mortality for the United States could be explained by the higher prevalence of MS and MS plus baseline CVD history than in Japan. In conclusion, the present study is the first to quantitatively demonstrate that MS and MS plus baseline CVD history may significantly contribute to the explanation of excess CVD mortality in the United States compared with Japan.The American journal of cardiology 10/2013; · 3.58 Impact Factor