Effect of chronic treatment with three varieties of Lepidium meyenii (Maca) on reproductive parameters and DNA quantification in adult male rats
ABSTRACT The aim of this study was to evaluate the chronic effect of different varieties of Lepidium meyenii (Red Maca, Yellow Maca and Black Maca). Male rats were treated by gavage with aqueous extract of each variety of maca equivalent to 1 g hypocotyl kg(-1) body weight (BW) for 84 days. At the end of the treatment, daily sperm production (DSP), epididymal sperm count (ESC) and sperm count in vas deferens (SCVD) were assessed. In addition, testis DNA quantification was also determined. Any toxic effect was assessed in liver and spleen by histological studies. The results indicate that Yellow Maca and Black Maca improved ESC and that three varieties of maca increased the SCVD without affecting DSP. Moreover, testis DNA levels were not affected by treatment with any of the three varieties of maca. Histological picture of the liver in animals treated with the three varieties of maca was similar to that observed in controls. In conclusion, Yellow and Black Maca increased epididymal sperm count after 84 days of treatment without affecting DSP. Maca seems to act as a modulator of sperm count at the reproductive tract level.
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ABSTRACT: There is a large variety of food products intended for athletes and sportsmen on the market. These products are often advertised with claims such as enhancement of performance, ability for regeneration, or even with an influence on hormonal balance. In recent years, the number of such products marketed on the internet has been considerably increased. In this study, we have examined the marketing of `sports food' offered on the internet with special focus on products that are advertised as hormone-modulating or pharmaceutically active. Of the 79 controlled products, 44 (56 %) contained herbal ingredients such as Lepidium meyenii, Avena sativa, Tribulus terrestris or Trigonella foenum-graecum. The advertised effects of these herbs are in most cases scientifically unproven. An additional 17 products (22 %) contained pharmaceutically active substances in an inadmissible manner, including dehydroepiandrosterone, its 7-keto derivative, and somatotropine as well as some traditional herbal medicines such as extracts of Serenoa repens or of Mucuna pruriens, which contains L-dopa. To protect athletes from health risks as well as from financial fraud, procedures should be developed to place a high priority on controlling the grey market for such products on the internet.Deutsche Lebensmittel-Rundschau: Zeitschrift für Lebensmittelkunde und Lebensmittelrecht 09/2008; 104:415-422. · 0.06 Impact Factor
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ABSTRACT: Lepidium meyenii (Maca) is a cultivated root belonging to the brassica family used in the Andean region for its supposed aphrodisiac properties. We carried out a double-blind clinical trial on 50 Caucasian men affected by mild erectile dysfunction (ED), randomised to treatment with Maca dry extract, 2400 mg, or placebo. The treatment effect on ED and subjective well-being was tested administrating before and after 12 weeks the International Index of Erectile Function (IIEF-5) and the Satisfaction Profile (SAT-P). After 12 weeks of treatment, both Maca- and placebo-treated patients experienced a significant increase in IIEF-5 score (P < 0.05 for both). However, patients taking Maca experienced a more significant increase than those taking placebo (1.6 +/- 1.1 versus 0.5 +/- 0.6, P < 0.001). Both Maca- and placebo-treated subjects experienced a significant improvement in psychological performance-related SAT-P score, but the Maca group higher than that of placebo group (+9 +/- 6 versus +6 +/- 5, P < 0.05). However, only Maca-treated patients experienced a significant improvement in physical and social performance-related SAT-P score compared with the baseline (+7 +/- 6 and +7 +/- 6, both P < 0.05). In conclusion, our data support a small but significant effect of Maca supplementation on subjective perception of general and sexual well-being in adult patients with mild ED.Andrologia 04/2009; 41(2):95-9. DOI:10.1111/j.1439-0272.2008.00892.x · 1.17 Impact Factor
Chapter: Maca (Lepidium meyenii)[Show abstract] [Hide abstract]
ABSTRACT: Maca is a dietary supplement derived from the processed tuberous root of Lepidium meyenii Walpers. We herein present a comprehensive review of the published literatures on maca, which includes morphological descriptions, traditional uses, nutritional status, chemical constituents, biological activities, cosmetic uses, and standardization. This review also provides an analysis of in vitro and in vivo biological activity, including clinical studies of various crude extracts from different types of maca for its uses for nutritional, chemoprevention, aphrodisiac and fertility enhancing purposes. Based on a long history of traditional use of maca in Peru and elsewhere, a wide array of commercial maca products have gained popularity as dietary supplements throughout the world for aphrodisiac purposes, and to increase fertility and stamina, thereby reiterating the critical role of ethnopharmacology as a rich source of new dietary supplements.Encyclopedia of Dietary Supplement, 2nd Edition, Supplement 1 edited by Paul Coates, Marc R. Blackman, Gordon Cragg, Mark Levine, Joel Moss, Jeffrey White, 01/2010: chapter Maca (Lepidium meyenii); Supplement 1: pages 522-531; Marcel Dekker, New York.