Effect of chronic treatment with three varieties of Lepidium meyenii (Maca) on reproductive parameters and DNA quantification in adult male rats.
ABSTRACT The aim of this study was to evaluate the chronic effect of different varieties of Lepidium meyenii (Red Maca, Yellow Maca and Black Maca). Male rats were treated by gavage with aqueous extract of each variety of maca equivalent to 1 g hypocotyl kg(-1) body weight (BW) for 84 days. At the end of the treatment, daily sperm production (DSP), epididymal sperm count (ESC) and sperm count in vas deferens (SCVD) were assessed. In addition, testis DNA quantification was also determined. Any toxic effect was assessed in liver and spleen by histological studies. The results indicate that Yellow Maca and Black Maca improved ESC and that three varieties of maca increased the SCVD without affecting DSP. Moreover, testis DNA levels were not affected by treatment with any of the three varieties of maca. Histological picture of the liver in animals treated with the three varieties of maca was similar to that observed in controls. In conclusion, Yellow and Black Maca increased epididymal sperm count after 84 days of treatment without affecting DSP. Maca seems to act as a modulator of sperm count at the reproductive tract level.
SourceAvailable from: Serol Korkmaz[Show abstract] [Hide abstract]
ABSTRACT: Maca (Lepidium meyenii) is a tuber root plant of the Brassicaceae family that grows on Andes mountain’s high altitude steps. Its tuber roots have rich nutrition contents and bioactive compounds as sterols, glucosinolates, alkaloids, alkamides (macaene, macamides), saponin and tanin. Beside of its traditional usage, the studies in recent years presented its capabilities that are energizer, aphrodisiac, improving reproduction, hormonal balancing, improving homeostasis, antioksidant, anticarcinogen and antistress. When Maca was used as a dietary additive at the many researches in humans and animals, no toxic effect was determined. Further studies are required to identify the compounds of Maca, their chemical structures, the mechanism of action and to use of Maca as a safe and natural feed additive in animal nutrition.
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ABSTRACT: For better development of the function composition of maca, combined ultrasonic and microwave method was used to extract glucosinolates of maca in this paper. The ultrasonic-microwave combined power, time, solution to solid ratio, and the volume fraction of ethanol were studied by conducting single factor tests. The optimization results showed that the collaborative of ultrasonic and microwave was in favour of extracting glucosinolates of maca. The best condition was that ultrasonic-microwave combined power 470W, time 70s, solution to solid ratio were 30:1(mL:g), and the volume fraction of ethanol was 66%, the actual content of glucosinolates of maca can reach to 0.51%, was 0.12% lower than Soxhlet extraction method.07/2012; 550-553:1893-1899. DOI:10.4028/www.scientific.net/AMR.550-553.1893
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ABSTRACT: Aim of the studyThe effect of Black maca (Lepidium meyenii) and Turraeanthus africanus on fertility and estrogenic activity in female mice was investigated.Materials and methodsThirty female mice were treated daily with extracts of Black maca plus T. africanus (BM+TA), T. africanus alone (TA) or vehicle (control) at dose 1 g/kg BW for 30 days.ResultsThe length of the estrous cycle inside the group of (BM+TA)-treated mice significantly (p < 0.001) shorten (4.08 ± 0.06 days) when compared to control (4.53 ± 0.05). On the proestrous stage, the oestradiol level for animals treated with TA (27.3 ± 0.5 pg/ml) and (BM+TA) (36.0 ± 0.9 pg/ml) significantly increased when compared to control (24.0 ± 0.4 pg/ml), while in the estrous stage only the estradiol level of (BM+TA) treated animal (28 ± 2 pg/ml) significantly increased (p < 0.01). The uterine weight of ovariectomized of TA-treated animals was higher (p < 0.05) than those observed in controls while no change in the (BM+TA) group was observed. The weight of uterus of non pregnant mice of both treated TA and (BM+TA) extract significantly increased (p < 0.001) in the proestrous and estrus stage when compared to control.The number of fetuses in the uterus after (BM+TA) treatment (14.66 ± 0.25) was significantly higher (p < 0.05) than the TA treated alone (13.60 ± 0.45) and the control (9.5 ± 1.10) one at day 15 of pregnancy.No significant difference between groups (p > 0.05) was observed for the two treatments concerning the Fertility index.ConclusionsTA can affect the number of embryo implantation and the uterine weight. This effect increased in association with BM. BM could regulate estrous cycle.European Journal of Integrative Medicine 09/2012; 4(3):e345–e351. DOI:10.1016/j.eujim.2012.03.001 · 0.65 Impact Factor