Low-grade myxofibrosarcoma invaded into the underlying skeletal muscle

Department of Dermatology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
The Journal of Dermatology (Impact Factor: 2.25). 09/2007; 34(8):561-4. DOI: 10.1111/j.1346-8138.2007.00331.x
Source: PubMed


Myxofibrosarcoma is a rare, soft-tissue sarcoma which is classified into three main subtypes according to cellularity and cell atypia: low, intermediate and high grade. A 44-year-old Japanese female presented with a low-grade myxofibrosarcoma on the left forearm. The lesion was completely resected. Histopathologically, the tumor was remarkably hypocellular and exhibited only mild atypia. However, it rapidly invaded into the underlying brachioradial muscle. The present case clearly indicated that a low-grade myxofibrosarcoma can invade into the deeper tissues including muscle even though its histological grade is very low.

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    • "High grade tumors, however, are hypercellular, malignant fibrous histiocytoma-like tumors with less myxoid tissue than their lower grade counterparts and present with multinucleated giants cells, increased mitotic activity, and areas of necrosis [4] [5] [7] [9]. These tumors stain positive for vimentin, CD34, and occasionally actin [3] [7] [8]. Gross presentation is most often of a slowgrowing , painless, palpable and ill-defined subcutaneous mass [1, 4]. "
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    ABSTRACT: Myxofibrosarcoma is a common connective tissue neoplasm of malignant fibrocytes in a myxoid matrix favoring the extremities. Like many other tumors of connective tissue, soft tissue sarcoma exhibits high recurrence rates but is rarely known to metastasize. We present a patient with myxofibrosarcoma of the hand with metastases to the lungs, pleura, and mediastinum. The mediastinal metastasis presented clinically with gastrointestinal symptoms due to compression of the gastroesophageal junction. To our knowledge, this is the first report of metastatic myxofibrosarcoma of the hand and also the first report of metastatic myxofibrosarcoma to mediastinal lymph nodes at the level of the gastroesophageal junction. We also performed a comprehensive literature review of metastatic myxofibrosarcoma.
    International Journal of Clinical and Experimental Medicine 01/2012; 5(1):92-5. · 1.28 Impact Factor
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    ABSTRACT: Myxofibrosarcoma, previously known as malignant fibrous histiocytoma, myxoid variant, is a rare tumor of mesenchymal origin, composed of spindle cells and myxoid stroma. It mainly affects elderly people, involving the lower extremities and frequently extending to the dermis and subcutaneous tissue. The tumor presents high rates of recurrence, and a deep biopsy is required to obtain the correct diagnosis. We report a case of high-grade mixofibrossarcoma characterized by a rapidly growing tumor and the presence of marked cellular pleomorphism and an abundant myxoid matrix.
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    ABSTRACT: O mixofibrossarcoma, previamente conhecido como histiocitoma fibroso maligno, variante mixoide, é um tumor raro, de origem mesenquimal, composto por células fusiformes e estroma mixoide. Acomete mais idosos, envolvendo extremidades inferiores e estendendo-se, em sua maior parte, até a derme e o subcutâneo. Apresenta altas taxas de recorrência e para seu diagnóstico é fundamental a realização de uma biópsia profunda. Relataremos o caso de um mixofibrossarcoma de alto grau, caracterizado por lesão tumoral de crescimento rápido e pela presença de marcado pleomorfismo celular e componente mixoide em abundância.
    Anais Brasileiros de Dermatologia 08/2011; 86(4):110-113. DOI:10.1590/S0365-05962011000700029 · 0.72 Impact Factor