Article

In vivo effects of bisphenol A in laboratory rodent studies. Reprod Toxicol

U.S. Geological Survey, Columbia Environmental Research Center, Columbia, MO 65201, United States.
Reproductive Toxicology (Impact Factor: 2.77). 08/2007; 24(2):199-224. DOI: 10.1016/j.reprotox.2007.06.004
Source: PubMed

ABSTRACT Concern is mounting regarding the human health and environmental effects of bisphenol A (BPA), a high-production-volume chemical used in synthesis of plastics. We have reviewed the growing literature on effects of low doses of BPA, below 50 mg/(kg day), in laboratory exposures with mammalian model organisms. Many, but not all, effects of BPA are similar to effects seen in response to the model estrogens diethylstilbestrol and ethinylestradiol. For most effects, the potency of BPA is approximately 10-1000-fold less than that of diethylstilbestrol or ethinylestradiol. Based on our review of the literature, a consensus was reached regarding our level of confidence that particular outcomes occur in response to low dose BPA exposure. We are confident that adult exposure to BPA affects the male reproductive tract, and that long lasting, organizational effects in response to developmental exposure to BPA occur in the brain, the male reproductive system, and metabolic processes. We consider it likely, but requiring further confirmation, that adult exposure to BPA affects the brain, the female reproductive system, and the immune system, and that developmental effects occur in the female reproductive system.

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    • "One of these EDCs widely found in the environment is bisphenol A (BPA). Animal studies have shown that in utero exposure to BPA produces prenatal and postnatal adverse effects on multiple tissues, including the brain (Richter et al. 2007). Prenatal BPA exposure affects brain development, sexual differentiation, social and anxiety-like behavior, and learning/memory ( "
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    • "The result indicated that the concentrations differ depending on the areas, mostly were lower than the limit of detection (<LOD 1 μg/L). Even though the concentrations were below LOD, it still gives effects in animals such as genital malformations, sexually dimorphic circuits in the hypothalamus, prostate weight and cancer, onset of estrus cyclicity and earlier puberty, mammary gland organization and cancer, low body weight, protein induction in the uterus, and many others (Richter et al. 2007). Recent results of molecular mechanisms of BPA action have revealed that at a very low concentration of BPA can still stimulate cellular response by a variety of pathways (Welshons et al. 2006). "
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    ABSTRACT: The potential of agricultural waste materials for the removal bisphenol A (BPA) from aqueous solution was investigated. BPA is an endocrine-disrupting compound (EDC) used mainly in the plastic manufacturing industry. It may be hazardous to humans and animals because of its estrogenic activity. Agricultural wastes are sustainable adsorbents because of their low cost and availability. Hence, this study investigated the removal of BPA from water by adsorption onto treated coir pith, coconut shell and durian peel. The adsorption of BPA from water onto adsorbent was evaluated using field emission scanning electron microscopy (FESEM), Fourier transform infrared spectroscopy (FTIR), and Brunauer-Emmett-Teller (BET). The effects of morphology, functional groups, and surface area on adsorption before and after pretreatment with sulfuric acid and reaction were investigated, and it was found that the treated adsorbent were able to remove BPA. Carbonyl and hydroxyl groups had appear in large number in FTIR analysis. The present study indicates that coir pith had removed 72 % of BPA with adsorption capacity of 4.308 mg/g for 24 h, followed by durian peel (70 %, 4.178 mg/g) and coconut shell (69 %, 4.159 mg/g). The results proved that these modified phyto-waste were promising materials as alternative adsorbent for the removal of BPA from aqueous solution.
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    • "treated alligators were heavier, larger, and fatter than control alligators at age 5 weeks but were leaner than controls at age 21 weeks. Developmental exposure to estrogenic compounds is often associated with increased body weight (reviewed in (Richter et al., 2007)), although decreased body weight has also been reported. For example, Honma et al. (2002) demonstrated that mice exposed in utero to DES (0.02 or 0.2 μg/kg) or BPA (2 or 20 μg/kg) produced lighter female offspring compared to controls (Honma et al., 2002). "
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