Article

Association between Serum Concentrations of Persistent Organic Pollutants and Self-Reported Cardiovascular Disease Prevalence: Results from the National Health and Nutrition Examination Survey, 1999–2002

Department of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, Daegu, Korea.
Environmental Health Perspectives (Impact Factor: 7.98). 08/2007; 115(8):1204-9. DOI: 10.1289/ehp.10184
Source: PubMed

ABSTRACT There is now increasing evidence that exposure to persistent organic pollutants (POPs) can contribute to the development of inflammatory diseases such as atherosclerosis.
The objective of this study was to examine associations of serum concentrations of POPs with self-reported history of cardiovascular disease (CVD).
Cross-sectional associations of serum POPs concentrations with the prevalence of self-reported CVD were investigated in 889 adults >or= 40 years of age in the National Health and Nutrition Examination Survey, 1999-2002. We selected 21 POPs [3 polychlorinated dibenzo-p-dioxins (PCDDs), 3 polychlorinated dibenzofurans (PCDFs), 5 dioxin-like polychlorinated biphenyls (PCBs), 6 nondioxin-like PCBs, and 4 organochlorine (OC) pesticides] because they were detectable in >or= 60% of participants.
Dioxin-like PCBs, nondioxin-like PCBs, and OC pesticides were positively associated with the prevalence of CVD only among females. Compared with those in the lowest quartile of serum concentration, the odds ratios for CVD across increasing quartiles were 0.9, 2.0, and 5.0 for dioxin-like PCBs (p for trend < 0.01), 1.2, 1.2, and 3.8 for nondioxin-like PCBs (p for trend < 0.01), and 1.9, 1.7, and 4.0 for OC pesticides (p for trend = 0.03). PCDDs showed positive trends with the prevalence of CVD in both males and females; adjusted odds ratios were 1.4, 1.7, and 1.9 (p for trend = 0.07, males and females combined).
Our findings need to be carefully interpreted because of the cross-sectional design and use of self-reported CVD. Prospective studies are needed to clarify these associations.

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    • "Janesick and Blumberg (2011) recently reported that environmental chemicals such as persistent organic pollutants (POPs) may play an important role in modulating the balance between energy intake and expenditure. Serum levels of POPs, such as polychlorinated biphenyls (PCBs), polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and organochlorine pesticides may be associated with body mass index, elevated triglyceride levels, abdominal obesity, and cardiovascular diseases (Airaksinen et al. 2011; Ha et al. 2007; Lee et al. 2012; Uemura et al. 2009). In animal studies, POPs—including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), 1,2,3,4,7,8-hexachlorodibenzo-p-dioxin, 3,3´,4,4´-tetrachlorobiphenyl (PCB-77), 3,3´,4,4´,5-pentachlorobiphenyl (PCB-126), 2,2´,4,4´,5,5´-hexachlorobiphenyl (PCB-153), and POP mixtures in crude salmon oil—have been associated with body weight gain, insulin resistance, abdominal obesity, hepatosteatosis, and atherosclerosis (Arsenescu et al. 2008; Ruzzin et al. 2010). "
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