Comparison of hydrogenated vegetable shortening and nutritionally complete high-fat diet on limited access-binge behavior in rats

University of Cincinnati, Department of Psychiatry, ML # 0506, Reading, OH 45237, United States.
Physiology & Behavior (Impact Factor: 3.03). 01/2008; 92(5):924-30. DOI: 10.1016/j.physbeh.2007.06.024
Source: PubMed

ABSTRACT Previous studies have suggested that intermittent exposure to hydrogenated vegetable shortening yields a binge/compensate pattern of feeding in rats. The present study was designed to assess whether rats would exhibit similar patterns of intake when given intermittent access to a nutritionally complete high-fat diet. Four groups of rats received varying exposure to either hydrogenated vegetable shortening or high-fat diet for 8 consecutive weeks. Animals were given daily and intermittent access to determine if the binge/compensate pattern of feeding was frequency dependent. At the conclusion of the study, body composition and plasma leptin levels were assessed to determine effects of diet and binge/compensate intake on endocrine alterations. As predicted, animals receiving intermittent access to high-fat diet displayed the binge/compensate pattern of feeding and appeared to compensate as a result of the caloric overload accompanying a particular binge episode. In addition, exposure to either shortening or high-fat diet led to alterations in body composition, while only exposure to shortening altered plasma leptin levels. These results suggest that binge-intake behavior occurs on a nutritionally complete high-fat diet and that this regimen is capable of altering both body composition and endocrine profile.

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    • "Highly palatable food activates dopaminergic neurons in the ventral tegmental area (VTA) projecting to the nucleus accumbens (NAc), amygdala and prefrontal cortex, areas involved in different aspects of reward behavior. For example when repeatedly exposed to sucrose for a short period of time after food restriction, rats show addictive behavior with food binges related to dopamine release in the NAc shell [30] and repetitive restricted exposure to fat induces similar changes [31] [32]. Long-term access to palatable food, however, will "
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