The response of mammalian cells to double-stranded RNA.

Michael P Gantier, Bryan R G Williams

Monash Institute of Medical Research, Monash University, Clayton, VIC, Australia.

Journal Article: Cytokine & Growth Factor Reviews (impact factor: 6.49). 18(5-6):363-71. DOI: 10.1016/j.cytogfr.2007.06.016

Abstract

Double-stranded RNA (dsRNA) has long been recognized as a central component of the interferon (IFN) system. It was originally characterized as a key mediator of IFN induction in response to virus infection. Subsequently, it was identified as a prime activator of the antiviral response. In recent years the discovery of the RNA interference (RNAi) pathway in mammals has renewed interest in dsRNA-mediated cellular responses. This has coincided with the identification of key components of the IFN induction pathway. Here, we present an overview of the current knowledge of dsRNA-mediated pathways in mammalian cells and introduce a link between these pathways and application of RNAi.

Source: PubMed

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Keywords

antiviral response
 
Double-stranded RNA
 
dsRNA
 
dsRNA-mediated cellular responses
 
dsRNA-mediated pathways
 
IFN induction
 
IFN induction pathway
 
key components
 
key mediator
 
mammalian cells
 
overview
 
RNA interference
 
RNAi