Article

Stress-induced remodeling of lymphoid innervation

Norman Cousins Center for PNI, Semel Institute for Neuroscience and Human Behavior, UCLA School of Medicine, USA.
Brain Behavior and Immunity (Impact Factor: 6.13). 02/2008; 22(1):15-21. DOI: 10.1016/j.bbi.2007.06.011
Source: PubMed

ABSTRACT Lymphoid organs have long been known to harbor neural fibers from the sympathetic division of the autonomic nervous system, but recent studies suggest a surprising degree of plasticity in the density of innervation. This review summarizes data showing that behavioral stress can increase the density of catecholaminergic neural fibers within lymphoid organs of adult primates. Stress-induced neural densification is associated with increased expression of neurotrophic factors, and functional consequences include alterations in lymph node cytokine expression and increased replication of a lymphotropic virus. The finding that behavioral stress can tonically alter lymph node neural structure suggests that behavioral factors could exert long-term regulatory influences on the initiation, maintenance, and resolution of immune responses.

Download full-text

Full-text

Available from: John P Capitanio, Aug 28, 2015
0 Followers
 · 
85 Views
  • Source
    • " , signaling and targets of sympathetic nerves in lymphoid organs ( Felten et al . , 1985 ; Felten and Felten , 1988 ; Felten , 1991 ; Straub , 2004 ) , the effect of age ( Bellinger et al . , 1992 ; Madden et al . , 1995 , 1997 , 1998 ; Friedman and Irwin , 1997 ) and stress ( Irwin , 1994 ; Marshall and Agarwal , 2000 ; Nagatomi et al . , 2000 ; Sloan et al . , 2008 ) as well as the relevance of dysregulated sympathetic nerovus system in immune - mediated disease ( Bellinger et al . , 1992 , 2008 ; Madden et al . , 1995 ; Friedman and Irwin , 1997 ; Marshall and Agarwal , 2000 ; Frohman et al . , 2001 ; Straub et al . , 2006 ; Wrona , 2006 ; del Rey and Besedovsky , 2008 ; Benarroch , 2009 ) ."
    [Show abstract] [Hide abstract]
    ABSTRACT: Innervation of the bone marrow (BM) has been described more than one century ago, however the first in vivo evidence that sympathoadrenergic fibers have a role in hematopoiesis dates back to less than 25 years ago. Evidence has since increased showing that adrenergic nerves in the BM release noradrenaline and possibly also dopamine, which act on adrenoceptors and dopaminergic receptors (DR) expressed on hematopoietic cells and affect cell survival, proliferation, migration and engraftment ability. Remarkably, dysregulation of adrenergic fibers to the BM is associated with hematopoietic disturbances and myeloproliferative disease. Several adrenergic and dopaminergic agents are already in clinical use for non-hematological indications and with a usually favorable risk-benefit profile, and are therefore potential candidates for non-conventional modulation of hematopoiesis.
    Frontiers in Cellular Neuroscience 09/2015; 9. DOI:10.3389/fncel.2015.00302 · 4.18 Impact Factor
  • Source
    • "A third pathway by which adverse social conditions can induce persistent transcriptional alterations in immune cells involves up-regulation of the NGF gene that supports the growth and differentiation of the SNS nerve fibers innervating lymph nodes [29]. The resulting increase in neurotransmitter delivery to the lymph node increases throughput from the brain to the immune system and thereby induces a persistent shift in the gene regulatory program of the tissue-resident pool of cells (e.g., down-regulating Type I interferon transcription and host resistance to viral infection [29]). "
    [Show abstract] [Hide abstract]
    ABSTRACT: A growing literature in human social genomics has begun to analyze how everyday life circumstances influence human gene expression. Social-environmental conditions such as urbanity, low socioeconomic status, social isolation, social threat, and low or unstable social status have been found to associate with differential expression of hundreds of gene transcripts in leukocytes and diseased tissues such as metastatic cancers. In leukocytes, diverse types of social adversity evoke a common conserved transcriptional response to adversity (CTRA) characterized by increased expression of proinflammatory genes and decreased expression of genes involved in innate antiviral responses and antibody synthesis. Mechanistic analyses have mapped the neural "social signal transduction" pathways that stimulate CTRA gene expression in response to social threat and may contribute to social gradients in health. Research has also begun to analyze the functional genomics of optimal health and thriving. Two emerging opportunities now stand to revolutionize our understanding of the everyday life of the human genome: network genomics analyses examining how systems-level capabilities emerge from groups of individual socially sensitive genomes and near-real-time transcriptional biofeedback to empirically optimize individual well-being in the context of the unique genetic, geographic, historical, developmental, and social contexts that jointly shape the transcriptional realization of our innate human genomic potential for thriving.
    PLoS Genetics 08/2014; 10(8):e1004601. DOI:10.1371/journal.pgen.1004601 · 8.17 Impact Factor
  • Source
    • "Author's personal copy system in stress responses (Irwin 1994; Sloan et al. 2008) and in the development and progression of immune-mediated diseases (Madden et al. 1995; Friedman and Irwin 1997; Marshall and Agarwal 2000; Frohman et al. 2001; Wrona 2006; Straub et al. 2006; Bellinger et al. 2008; Benarroch 2009). "
    [Show abstract] [Hide abstract]
    ABSTRACT: Sympathoadrenergic pathways are crucial to the communication between the nervous system and the immune system. The present review addresses emerging issues in the adrenergic modulation of immune cells, including: the specific pattern of adrenoceptor expression on immune cells and their role and changes upon cell differentiation and activation; the production and utilization of noradrenaline and adrenaline by immune cells themselves; the dysregulation of adrenergic immune mechanisms in disease and their potential as novel therapeutic targets. A wide array of sympathoadrenergic therapeutics is currently used for non-immune indications, and could represent an attractive source of non-conventional immunomodulating agents.
    Amino Acids 12/2011; 45(1). DOI:10.1007/s00726-011-1186-6 · 3.65 Impact Factor
Show more