Article

Interleukin-12 and tuberculosis: an old story revisited.

The Trudeau Institute, Inc. 154 Algonquin Ave. Saranac Lake, NY 12983, USA.
Current Opinion in Immunology (impact factor: 9.52). 09/2007; 19(4):441-7. DOI:10.1016/j.coi.2007.07.004 pp.441-7
Source: PubMed

ABSTRACT Our understanding of the role of interleukin (IL)-12 in controlling tuberculosis has expanded because of increased interest in other members of the IL-12 family of cytokines. Recent data show that IL-12, IL-23 and IL-27 have specific roles in the initiation, expansion and control of the cellular response to tuberculosis. Specifically, IL-12, and to a lesser degree IL-23, generates protective cellular responses and promotes survival, whereas IL-27 moderates the inflammatory response and is required for long-term survival. Paradoxically, IL-27 also limits bacterial control, suggesting that a balance between bacterial killing and tissue damage is required for survival. Understanding the balance between IL-12, IL-23 and IL-27 is crucial to the development of immune intervention in tuberculosis.

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Keywords

IL-12 family
 
IL-27 moderates
 
inflammatory response
 
initiation
 
lesser degree IL-23
 
protective cellular responses
 
Recent data
 
tissue damage
 
tuberculosis