Scatter factor-dependent branching morphogenesis: structural and histological features.

Abstract

Branching morphogenesis is a multi-step process that controls the formation of polarised tubules starting from hollow cysts. Its execution entails a series of rate-limiting events which include reversible disruption of cell polarity, dismantling of intercellular contacts, acquisition of a motile phenotype, stimulation of cell proliferation, and final re-establishment of cell polarity for creation of the definitive structures. Branching morphogenesis takes place physiologically during development, accounting for the establishment of organs endowed with a ramified architecture such as glands, the respiratory tract and the vasculartree. In cancer, aberrant implementation of branching morphogenesis leads to deregulated proliferation, protection from apoptosis and enhanced migratory/invasive properties, which together exacerbate the aggressive features of neoplastic cells. Under both physiological and pathological conditions, branching morphogenesis is mainly accomplished by a family of growth factors known as scatter factors. In this review, we will summarise the current knowledge on the biological and functional roles of scatter factors during branching morphogenesis, with a special emphasis on the phenotypic (structural and histological) consequences of scatter factor activity in different tissues.

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european journal of histochemistry
a journal of functional cytology
ISSN 1121-760X
volume 51/supplement 1
2007
under the auspices of
the University of Pavia, Italy
Trimestrale – Sped. Abb. Post. – 45% art. 2, comma 20B, Legge 662/96 - Filiale di Pavia. Il mittente chiede la restituzione dei fascicoli non consegnati impegnandosi a pagare le tasse dovute
The Fathers of Italian Histology
Guest Editors
F.A. Manzoli, P . Carinci

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TABLE OF CONTENTS
Osteogenic and chondrogenic differentiation: comparison of human and
rat bone marrow mesenchymal stem cells cultured into polymeric scaffolds
B. Zavan, C. Giorgi, G.P. Bagnara,V.Vindigni, G. Abatangelo, R. Cortivo ...................1-8
Tendon crimps and peritendinous tissues responding to tensional forces
M. Franchi, M. Quaranta,V. De Pasquale, M. Macciocca, E. Orsini, A.Triré,V. Ottani,
A. Ruggeri ............................................................................................................9-14
The mechanism of transduction of mechanical strains into biological signals
at the bone cellular level
G. Marotti, C. Palumbo .......................................................................................15-20
Cytoskeletal reorganization in skeletal muscle differentiation:
from cell morphology to gene expression
L. Formigli, E. Meacci, S. Zecchi-Orlandini, G.E. Orlandini....................................21-28
Sarcoglycan subcomplex in normal and pathological human muscle fibers
G. Anastasi, G. Cutroneo, G. Rizzo, A. Favaloro ....................................................29-34
Stem cell-mediated muscle regeneration and repair in aging and neuromuscular
diseases
A. Musarò, C. Giacinti, L. Pelosi, G. Dobrowolny, L. Barberi, C. Nardis, D. Coletti,
B.M. Scicchitano, S. Adamo, M. Molinaro............................................................35-44
Anatomy of emotion: a 3D study of facial mimicry
V. F. Ferrario, C. Sforza.......................................................................................45-52
New findings on 3-D microanatomy of cellular structures in human tissues
and organs.An HRSEM study
A. Riva, F. Loy, R. Isola, M. Isola, G. Conti, A. Perra, P. Solinas, F.Testa Riva........53-58
Non-traditional large neurons in the granular layer of the cerebellar cortex
G. Ambrosi, P. Flace, L. Lorusso, F. Girolamo, A. Rizzi, L. Bosco, M. Errede,
D.Virgintino, L. Roncali,V. Benagiano ................................................................59-64
The solitary chemosensory cells and the diffuse chemosensory system
of the airway
F. Osculati, M. Bentivoglio, M. Castellucci, S. Cinti, C. Zancanaro, A. Sbarbati.......65-72
The modality of transendothelial passage of lymphocytes and tumor cells
in the absorbing lymphatic vessel
G. Azzali.............................................................................................................73-78
Scatter factor-dependent branching morphogenesis:
structural and histological features
P. Comoglio, L.Trusolino, C. Boccaccio.................................................................79-92
Models of epithelial histogenesis
A. Casasco, M. Casasco, A.Icaro Cornaglia, F. Riva, A. Calligaro .........................93-100
Adult stem cells: the real root into the embryo?
G. Zummo, F. Bucchieri, F. Cappello, M. Bellafiore, G. La Rocca, S. David,
V. Di Felice, R. Anzalone, G. Peri, A. Palma, F. Farina.......................................101-104
Extracellular matrix and growth factors in the pathogenesis of some craniofacial
malformations
P. Carinci, E. Becchetti,T. Baroni, F. Carinci, F. Pezzetti, G. Stabellini,
P. Locci, L. Scapoli, M.Tognon, S.Volinia, M. Bodo..........................................105-116
The nuclear envelope, human genetic diseases and ageing
N.M. Maraldi, G. Mazzotti, R. Rana, A. Antonucci, R. Di Primio, L. Guidotti .....117-124
Nuclear phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3-kinase,
Akt, and PTEN: emerging key regulators of anti-apoptotic signaling
and carcinogenesis
A. M. Martelli, L. Cocco, S. Capitani, S. Miscia, S. Papa, F. A. Manzoli.............125-132
Neuroendocrine regulation and tumor immunity
R.Toni, P. Mirandola, G. Gobbi, M.Vitale.........................................................133-138
european journal
of histochemistry
ISSN 1121-760X
volume 51/supplement 1
2007
table of contents
ejh

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European Journal of Histochemistry — Vol. 51 supplement 1 2007 — pp. 1-140

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