Relationship between the adipose-tissue hormone resistin and coronary artery disease

Department of Medicine, Academic Teaching Hospital Feldkirch, A-6807 Feldkirch, Austria.
Clinica Chimica Acta (Impact Factor: 2.76). 01/2007; 386(1-2):1-6. DOI: 10.1016/j.cca.2007.07.001
Source: PubMed

ABSTRACT Data on the cardiovascular risk associated with the adipose-tissue-related hormone resistin are scarce.
We measured serum resistin and established vascular risk factors in 547 consecutive patients (age 63+/-10 years) undergoing coronary angiography for the evaluation of stable coronary artery disease. Prospectively, we recorded major coronary events and cumulative vascular events over 4 years.
60% of our patients had significant coronary stenoses with a lumen narrowing > or =50%. Serum resistin was moderately but significantly correlated with age (r=0.139; p=0.001), high-sensitivity C-reactive protein (hsCRP; r=0.228; p<0.001) and decreasing renal function (r=0.240; p<0.001). However, there was no significant difference of serum resistin between patients with CAD and those in whom angiography did not show CAD (4.5 [3.1-5.8] vs. 4.3 [3.4-5.3] ng/ml; p=0.545) and between patients with > or =50% coronary narrowings and those without such lesions (4.5 [3.2-5.9] vs. 4.3 [3.1-5.5] ng/ml; p=0.265). Prospectively, Cox regression analyses neither indicated an association between serum resistin and major coronary events nor between serum resistin and cumulative vascular events.
Among coronary patients serum resistin is significantly correlated with hsCRP, age and decreasing renal function but resistin is neither associated with the presence of significant coronary stenoses nor with the incidence of future vascular events.

  • [Show abstract] [Hide abstract]
    ABSTRACT: This paper reviews the role of single wafer processing in the development of sub-quarter micron silicon integrated circuits (ICs). The issues related to device processing, choice of materials, performance, reliability, and manufacturing are covered. Single wafer processing based rapid photothermal processing (dominant photons with wavelength less than about 800 nm) is an ideal answer to almost all the thermal processing requirements of current and future Si ICs
    Microelectronics, 1997. Proceedings., 1997 21st International Conference on; 10/1997
  • [Show abstract] [Hide abstract]
    ABSTRACT: The objective of the study was to assess the relation of resistin to the anthropometric parameters, metabolic risk factors, and C-reactive protein (CRP) in men with myocardial infarction. Subjects were 40 obese (age, 53.6 +/- 7.39 years; body mass index, > or =30 kg/m2) and 40 lean (age, 54.4 +/- 6.62 years; body mass index, <25 kg/m2) men with first acute myocardial infarction. Waist and hip circumferences, CRP, uric acid, fasting glucose, lipid profile, and blood resistin concentration were measured. In obese patients, triglycerides, fasting glucose, and CRP were significantly higher whereas high-density lipoprotein cholesterol was lower than in lean patients. The range of blood resistin concentration was 6.0 to 70.5 ng/mL: 27.84 +/- 12.15 ng/mL in obese subjects and 17.35 +/- 11.08 ng/mL in lean subjects (P < .0001). Significant positive correlation was revealed between blood resistin concentration and each of the analyzed anthropometric parameter and with fasting glucose, low-density lipoprotein cholesterol, and CRP, whereas negative relation was observed between resistin and high-density lipoprotein cholesterol. As revealed by univariate logistic regression analysis, risk of blood resistin concentration being greater than the median value (19.75 ng/mL) was increased by obesity, high-density lipoprotein cholesterol <40 mg/dL, hypertension, and CRP. In multivariate model, independent variables associated with higher median of resistin were obesity and CRP. Obesity increased 5.5-fold the probability of blood resistin concentration being greater than 19.75 ng/mL, whereas each 1-mg/dL increase in CRP increased this probability by 13%. In patients with acute myocardial infarction, obesity is positively related to blood resistin concentration. Resistin is likely to play a major role in the atherogenesis and its complications, and this action seems to be mostly related to the inflammatory reaction.
    Metabolism 05/2008; 57(4):488-93. DOI:10.1016/j.metabol.2007.11.009 · 3.61 Impact Factor
  • [Show abstract] [Hide abstract]
    ABSTRACT: Adiponectin and resistin, which have counteracting effects, are suggested to be associated with inflammation and atherosclerosis. The relationship between their levels and prognosis in high risk patients is, however, still unclear. The aim of this study was to evaluate the prognostic values of these adipokines in patients with acute myocardial infarction (MI). Adiponectin and resistin levels were measured at acute phase of MI in 397 consecutive patients. All patients were followed-up for the occurrence of all-cause and cardiovascular mortalities. Predictors for all-cause and cardiovascular mortalities were analyzed by Cox proportional hazard model. During the mean follow-up period of 12 months, 28 (7.1%) patients died. Unadjusted all-cause mortality rate was significantly higher in patients with high tertiles of adiponectin (P=0.002) and resistin (P=0.002) levels. After controlling of clinical and laboratory variables, age [95% confidence interval (CI): 1.20-2.83, P=0.006], adiponectin (95% CI: 1.01-1.22, P=0.040), resistin (95% CI: 1.06-2.33, P=0.025), and statin use (95% CI: 0.15-0.83, P=0.017) were found to be independent predictors of all-cause mortality. For cardiovascular mortality, only age (95% CI: 1.33-3.25, P=0.001) and renal insufficiency (95% CI: 1.52-12.22, P=0.006) were independent predictors. High plasma adiponectin and resistin levels were predictors for all-cause mortality independent of other risk factors in patients with acute MI. These results confirmed and extended the positive correlations between these adipokines and mortality to a population consisting exclusively of MI.
    Coronary artery disease 12/2008; 20(1):33-9. DOI:10.1097/MCA.0b013e328318ecb0 · 1.30 Impact Factor

Lorenz Risch