Van Lint, P. & Libert, C. Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation. J. Leukocyte Biol. 82, 1375-1381

Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium.
Journal of Leukocyte Biology (Impact Factor: 4.29). 01/2008; 82(6):1375-81. DOI: 10.1189/jlb.0607338
Source: PubMed

ABSTRACT The action of matrix metalloproteinases (MMPs) was originally believed to be restricted to degradation of the extracellular matrix; however, in recent years, it has become evident that these proteases can modify many nonmatrix substrates, such as cytokines and chemokines. The use of MMP-deficient animals has revealed that these proteases can indeed influence the progression of various inflammatory processes. This review aims to provide the reader with a concise overview of these novel MMP functions in relation to leukocyte migration.

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Available from: Philippe Van Lint, May 04, 2015
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    • "e l s e v i e r . c o m / l o c a t e / y b b r c induce cytoskeletal rearrangement and induce the cellular adhesion of neoplastic cells as well as their migration [13]. It has been well documented in literature that upregulation cellular inflammatory adhesion through chemokine–ligand, CXCL12–CXCR4, interactions play a critical role in the metastasis of breast cancer to lungs and lymph nodes [14]. "
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    Biochemical and Biophysical Research Communications 10/2014; 455(1-2). DOI:10.1016/j.bbrc.2014.10.124 · 2.30 Impact Factor
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    • "In addition to driving direct tissue destruction, MMPs can exert their functions on chemokines, thereby altering leukocyte recruitment. Chemokine digestion by MMPs can have several outcomes , ranging from functional inactivation, to the generation of antagonistic variants and to potentiation of chemotactic activity [63]. Inactivation of several chemokines has been shown to occur through MMP-mediated cleavage. "
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    Seminars in Immunology 10/2014; 26(6). DOI:10.1016/j.smim.2014.09.004 · 5.17 Impact Factor
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    • "Decreased relative expression of PECAM1 (−1.69-fold), which encodes a protein involved in the transmigration of leukocytes through or between endothelial layers into tissues during extravasation, was also detected in the present study (34). Furthermore, a reduction in relative expression was also observed for MMP9 (−1.79), which degrades the extracellular matrix facilitating the transmigration of leukocytes (35, 36). "
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    Frontiers in Immunology 08/2014; 5:396. DOI:10.3389/fimmu.2014.00396
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