Chemokine and cytokine processing by matrix metalloproteinases and its effect on leukocyte migration and inflammation

Department of Molecular Biomedical Research, Ghent University, Ghent, Belgium.
Journal of Leukocyte Biology (Impact Factor: 4.3). 01/2008; 82(6):1375-81. DOI: 10.1189/jlb.0607338
Source: PubMed

ABSTRACT The action of matrix metalloproteinases (MMPs) was originally believed to be restricted to degradation of the extracellular matrix; however, in recent years, it has become evident that these proteases can modify many nonmatrix substrates, such as cytokines and chemokines. The use of MMP-deficient animals has revealed that these proteases can indeed influence the progression of various inflammatory processes. This review aims to provide the reader with a concise overview of these novel MMP functions in relation to leukocyte migration.

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