Article

[Association between toll like receptor 4 (896A>G) mutations and pancreatic necrotic infection in severe acute pancreatitis].

Department of General Surgery, the General Hospital of Chinese People's Armed Police Forces, Beijing 100039, China.
Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 07/2007; 38(4):617-9.
Source: PubMed

ABSTRACT To determine the relationship between Toll like receptor (TLR) 4 (896A>G) mutations and pancreatic necrotic infection in acute pancreatitis (AP).
TLR4 (896A>G) mutations were detected by mispairing PCR-RFLP analysis technique in the patients with pancreatic necrosis and healthy volunteers.
(1) All of the TLR4 mutations were heterozygotes; (2) The G allele frequencies of TLR4 genes were significantly higher in the patients with pancreatic infection than in the healthy volunteers; (3) The incidence of gram-negative infection was significantly higher in the patients with the TLR4 mutations [15 (44.1%) of 34] than that in the wild type population [15(18.5%) of 81].
TLR4 (896A>G) mutations are associated with the infection of pancreatic necrosis in the patients with AP.

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Keywords

AP
 
G allele frequencies
 
healthy volunteers
 
mispairing PCR-RFLP analysis technique
 
pancreatic infection
 
pancreatic necrosis
 
pancreatic necrotic infection
 
patients
 
receptor
 
TLR4 mutations