[Show abstract][Hide abstract] ABSTRACT: We report an unusual case of atypical T-cell proliferation involving the lymphatic vessels within a cutaneous hemangioma from an elderly woman. Despite the blastic morphology, the CD4 restricted phenotype and the very high proliferation index, the clinical presentation (single skin lesion in a healthy woman), the benign clinical course and the absence of T-cell receptor (TCR) clonal rearrangement favored a reactive nature of the process. Since the atypical cells showed an effector/memory-like regulatory T-phenotype (CD45RO+, CD25+ and FOXp3+), expressed the migration-associated molecule CCR7 and were exclusively located within podoplanin+ lymphatic vessels, we speculate that the process might reflect an unusual local immune response, with migration of T-cells to draining lymph nodes.
Journal of Cutaneous Pathology 08/2009; 37(4):497-503. · 1.77 Impact Factor
[Show abstract][Hide abstract] ABSTRACT: Herein, we present the first report of a reactive atypical intravascular CD30+ T-cell proliferation. Our patient developed the condition after trauma, and he has followed a benign clinical course. This observation represents a potential diagnostic pitfall for intravascular lymphoma and adds to the list of reactive conditions that may be associated with an atypical CD30+ T-cell infiltrate.
Journal of Cutaneous Pathology 04/2009; 36(3):350-4. · 1.77 Impact Factor
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