Microbial biosensors.

Division of Chemical and Biomolecular Engineering and Centre of Biotechnology, Nanyang Technological University, Singapore 637722, Singapore.
Analytica chimica acta (Impact Factor: 4.31). 06/2006; 568(1-2):200-10. DOI: 10.1016/j.aca.2005.11.065
Source: PubMed

ABSTRACT A microbial biosensor is an analytical device that couples microorganisms with a transducer to enable rapid, accurate and sensitive detection of target analytes in fields as diverse as medicine, environmental monitoring, defense, food processing and safety. The earlier microbial biosensors used the respiratory and metabolic functions of the microorganisms to detect a substance that is either a substrate or an inhibitor of these processes. Recently, genetically engineered microorganisms based on fusing of the lux, gfp or lacZ gene reporters to an inducible gene promoter have been widely applied to assay toxicity and bioavailability. This paper reviews the recent trends in the development and application of microbial biosensors. Current advances and prospective future direction in developing microbial biosensor have also been discussed.

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    ABSTRACT: Cameroon-Nigeria-Italy scientific cooperation: veterinary public health and sustainable food safety to promote “one health/one prevention”. Edited by Chiara Frazzoli, Emmanuel Acha Asongalem and Orish Ebere Orisakwe 2012, vi, 198 p. Rapporti ISTISAN 12/49 Sub-Saharan Africa has often adopted a short-term view of human development relying on external financial support, whereas limited resources are invested in scientific research, technology, prevention and innovation as drivers of social and economic growth and long-term sustainable development. In a continent where products of animal origin have become fundamental in human diet, veterinary public health and food safety are called to face toxicological risk factors related to food-chain contamination, in particular those triggering poor health burden through vertical (mother to child) exposure. This report summarizes the current items of the Cameroon-Nigeria-Italy experience of scientific cooperation pivoting on a network crosscutting public institutions, universities, NGOs and social, professional and scientific organizations. The network promotes a “social toxicology” based on the proactive capability of local communities to widen the field of international cooperation to the prevention early in life of chronic multi-factorial diseases. This will contribute towards the mitigation of infant morbidity and mortality, the increase of healthy life expectancy in children and adults as well as the achievement of the Millennium Development Goals. Key words: Toxicology; Transgenerational exposure; Traslational prevention

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May 23, 2014