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Phytochemistry and pharmacognosy

Centre for pharmacognosy and Phytotherapy, The School of Pharmacy, University of London, 29-39 Brunswick Square, London WC1N 1AX, UK.
Phytochemistry (Impact Factor: 3.35). 11/2007; 68(22-24):2960-72. DOI: 10.1016/j.phytochem.2007.06.028
Source: PubMed

ABSTRACT During the past 50 years there have been tremendous advances in chemical and biological techniques of analysis that have transformed research in pharmacognosy. The PSE has regularly held symposia of relevance to pharmacognosy and some of these are briefly reviewed in the area of natural products from higher plants. These symposia have charted the developments that link pharmacognosy with phytochemistry and illustrate the application of increasingly more sophisticated analytical techniques to the discovery of biologically active compounds. Plants have yielded clinical drugs, either as natural product molecules, or as synthetic modifications, particularly for chemotherapeutic treatment of cancer and malaria. Aspects of biotechnology, traditional medicines and herbal medicinal products are briefly discussed.

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    • "These elements are selected examples that show how zoology and pharmacology are linked and how important describing the interactions between both fields could contribute in the development of the two fields both at the experimental and at the theoretical level. Furthermore, combining data provided by the related fields such as pharmacognosy (Ghanemi and Boubertakh, 2014) especially by studying the properties of chemical (Ghanemi, 2014a,e) or natural products (Boubertakh et al., 2013; Phillipson, 2007) on cells, biochemistry (Ghanemi, 2013b) and cellular biology will surely be very beneficial to a better mapping of the bridges between zoology and pharmacology toward deeper understanding and further advances. "
    01/2015; 23. DOI:10.1016/j.jobaz.2014.12.003
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    • "Evidence-Based Complementary and Alternative Medicine but also in a number of food and pharmaceutical products, due to their high content of phenolic compounds, their nutritional properties, and bioactivity [8]. Thymus capitata is a Mediterranean herb of the Lamiaceae family that grows mainly in northern Tunisia [9]. "
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    ABSTRACT: The chemical composition, antioxidant and antimicrobial activities, and the preservative effect of Thymus capitata essential oil against Listeria monocytogenes inoculated in minced beef meat were evaluated. The essential oil extracted was chemically analyzed by gas chromatography-mass spectrometry. Nineteen components were identified, of which carvacrol represented (88.89%) of the oil. The antioxidant activity was assessed in vitro by using both the DPPH and the ABTS assays. The findings showed that the essential oil exhibited high antioxidant activity, which was comparable to the reference standards (BHT and ascorbic acid) with IC50 values of 44.16 and 0.463 μ g/mL determined by the free-radical scavenging DPPH and ABTS assays, respectively. Furthermore, the essential oil was evaluated for its antimicrobial activity using disc agar diffusion and microdilution methods. The results demonstrated that the zone of inhibition varied from moderate to strong (15-80 mm) and the minimum inhibition concentration values ranged from 0.32 to 20 mg/mL. In addition, essential oil evaluated in vivo against Listeria monocytogenes showed clear and strong inhibitory effect. The application of 0.25 or 1% (v/w) essential oil of T. capitata to minced beef significantly reduced the L. monocytogenes population when compared to those of control samples (P-value <0.01).
    Evidence-based Complementary and Alternative Medicine 02/2014; 2014:152487. DOI:10.1155/2014/152487 · 1.88 Impact Factor
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    • "e use of medicinal plants throughout thousands of years by these populations allowed accumulation of empirical knowledge of their utility, which demands adequate evaluation of efficacy, safety, and action mechanisms [1]. e therapeutic properties of certain medicinal plants are generally related to their content of secondary metabolites, such as polyphenols, terpenes, phytosteroids, and alkaloyds, among others, which are produced in considerable amounts and variable proportions [2]. Essential oils are concentrated volatile aromatic compounds produced by aromatic plants, such as Cymbopogon winterianus Jowitt (Poaceae), Cymbopogon citrates Stapf (Poaceae), �avandula multi�da Linnaeus (Lamiaceae), and ymus pubescens Boiss. "
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    ABSTRACT: Objective. To evaluate antinocicpetive and redox properties of the monoterpenes (+)-camphene, p-cymene, and geranyl acetate in in vivo and in vitro experimental models. Methods. Evaluation of the in vitro antioxidant activity of (+)-camphene, p-cymene, and geranyl acetate using different free radical-generating systems and evaluation of antinociceptive actions by acetic acid-induced writhing and formalin-induced nociception tests in mice. Results. p-Cymene has the strongest antinociceptive effect, but (+)-camphene and geranyl acetate also present significant activity at high doses (200 mg/kg). (+)-Camphene had the strongest antioxidant effect in vitro at TBARS and TRAP/TAR assays and also had the highest scavenging activities against different free radicals, such as hydroxyl and superoxide radicals. Sodium nitroprussiate-derived NO production was enhanced by (+)-camphene. Geranyl acetate and p-cymene also presented some antioxidant effects, but with a varying profile according the free radical-generating system studied. Conclusion. (+)-Camphene, p-cymene, and geranyl acetate may present pharmacological properties related to inflammation and pain-related processes, being potentially useful for development of new therapeutic strategies, with limited possibilities for p-cymene and geranyl acetate.
    01/2013; 2013:459530. DOI:10.1155/2013/459530
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