Garlic, Vitamin, and Antibiotic Treatment for Helicobacter pylori: A Randomized Factorial Controlled Trial

NCI-Frederick, Фредерик, Maryland, United States
Helicobacter (Impact Factor: 4.11). 11/2007; 12(5):575-8. DOI: 10.1111/j.1523-5378.2007.00528.x
Source: PubMed
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    • "However, dietary intervention studies have been relatively less successful than in vivo and in vitro experimental studies. The effects of curcumin, vitamin C, vitamin E, selenium, and garlic have been investigated in individuals infected with H. pylori [57–60]. However, they showed limited or no effects on bacterial load or the inflammatory response induced by H. pylori. "
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    ABSTRACT: Helicobacter pylori is an important risk factor for gastric inflammation, which is mediated by multiple signaling pathways. The aim of this study was to investigate the effects of polyunsaturated fatty acids (PUFAs), such as linoleic acid (LA), alpha-linolenic acid (ALA), and docosahexaenoic acid (DHA), on the expression of the proinflammatory chemokine interleukin-8 (IL-8) in H. pylori-infected gastric epithelial AGS cells. To investigate whether PUFAs modulate H. pylori-induced inflammatory signaling, we determined the activation of epidermal growth factor receptor (EGFR), protein kinase C- δ (PKC δ ), mitogen-activated protein kinases (MAPKs), nuclear factor-kappa B (NF- κ B), and activator protein-1 (AP-1) as well as IL-8 expression in H. pylori-infected gastric epithelial cells that had been treated with or without PUFAs. We found that PUFAs inhibited IL-8 mRNA and protein expression in H. pylori-infected cells. ω -3 fatty acids (ALA, and DHA) suppressed the activation of EGFR, PKC δ , MAPK, NF- κ B, and AP-1 in these infected cells. LA did not prevent EGFR transactivation and exhibited a less potent inhibitory effect on IL-8 expression than did ALA and DHA. In conclusion, PUFAs may be beneficial for prevention of H. pylori-associated gastric inflammation by inhibiting proinflammatory IL-8 expression.
    Mediators of Inflammation 06/2014; 2014(196):128919. DOI:10.1155/2014/128919 · 3.24 Impact Factor
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    • "Similarly, turmeric/curcumin (Koosirirat et al., 2010), chili (Lee et al., 2007b), and oregano (Lin et al., 2005) have been shown to have varying levels of bacteriocidal effects against H. pylori. Furthermore, garlic extracts and its active ingredient , allicin, have been shown to contain H. pylori growth inhibitory properties when tested in vitro (Canizares et al., 2002, 2004), in vivo in animal models (Iimuro et al., 2002), as well as in clinical trials (Martin and Ernst, 2003; Gail et al., 2007). Moreover, several studies have shown a reduced risk of gastric cancer with increased consumption of allium containing vegetables such as onions and garlic (Jonkers et al., 1999); this effect may possibly be due to an effect on H. pylori. "
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    ABSTRACT: The Gram-negative pathogen Helicobacter pylori is increasingly more resistant to the three major antibiotics (metronidazole, clarithromycin and amoxicillin) that are most commonly used to treat infection. As a result, there is an increased rate of treatment failure; this translates into an overall higher cost of treatment due to the need for increased length of treatment and/or the requirement for combination or sequential therapy. Given the rise in antibiotic resistance, the complicated treatment regime, and issues related to patient compliance that stem from the duration and complexity of treatment, there is clearly a pressing need for the development of novel therapeutic strategies to combat H. pylori infection. As such, researchers are actively investigating the utility of antimicrobial peptides, small molecule inhibitors and naturopathic therapies. Herein we review and discuss each of these novel approaches as a means to target this important gastric pathogen.
    The Journal of Microbiology 04/2014; 52(4):259-72. DOI:10.1007/s12275-014-3603-5 · 1.44 Impact Factor
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    ABSTRACT: Objective|In cancer prevention, the targeting of precancerous lesions has been recognized as the most promising method. However, little attention has been paid to the risk factors of precancerous gastric lesions, especially in rural China where there is high prevalence of precancerous gastric lesions. We therefore conducted a cross-sectional study in Liaoning province, China, to investigate the potential risk and protective factors of these precancerous gastric lesions. MethodsA total of 1,179 subjects with high risk of gastric cancer from Zhuanghe County were included in this study. Standard questionnaires were used in collecting epidemiological factors and the data were then analyzed by the unconditional logistic regression model. ResultsSmoking and drinking were the risk factors for the precancerous gastric lesions among rural subjects, and the association of smoking or drinking and the precancerous gastric lesions increased in strength with the daily consumption and duration. As the factors such as age, gender, smoking, alcohol were controlled, a multivariable analysis revealed that there was a significant correlation between the deep-fry food intake and the gastric epithelial dysplasia with the odds ratio (OR) of 1.78 [95% confidence interval (CI): 1.01–3.12]. Garlic eating was shown to confer protection against the development of gastric ulcer (OR=0.55, 95% CI: 0.33–0.92). ConclusionSmoking and drinking were the risk factors for the precancerous gastric lesions among rural subjects. Deep-fry food intake might be one of the risk factors for the precancerous gastric lesions and garlic eating was shown to confer protection against the development of gastric ulcer among rural Chinese population. Key wordsRisk factors-Precancerous gastric lesions-High risk of gastric cancer CLC numberR735.2
    Chinese Journal of Cancer Research 12/2010; 22(4):267-273. DOI:10.1007/s11670-010-0267-5 · 1.94 Impact Factor
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