Article

Elevated serum levels of interferon- gamma -inducible protein-10 in patients coinfected with hepatitis C virus and HIV.

Centre for Research in Infectious Diseases, University College Dublin, Dublin, Ireland.
The Journal of Infectious Diseases (impact factor: 6.41). 11/2007; 196(7):1053-7. DOI:10.1086/520935 pp.1053-7
Source: PubMed

ABSTRACT Coinfection with hepatitis C virus (HCV) and human immunodeficiency virus (HIV) is associated with an accelerated course of HCV infection and a faster progression to severe liver disease. We have investigated whether the development of liver disease in coinfected patients is associated with specific chemokine and cytokine production. Four cohorts--HCV/HIV-coinfected patients, HCV-monoinfected patients, HIV-monoinfected patients, and healthy control subjects--were studied. Serum levels of the 10-kDa interferon- gamma -inducible protein (IP-10) were higher in all 3 groups of infected patients than in control subjects (P<.0001). HCV/HIV-coinfected patients had significantly higher IP-10 levels than monoinfected patients. In HCV-monoinfected patients, liver fibrosis scores and liver enzyme levels were positively correlated with IP-10 levels. Elevated IP-10 levels are associated with and may contribute to liver damage in both HCV-monoinfected and HCV/HIV-coinfected patients.

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Keywords

10-kDa interferon- gamma -inducible protein
 
accelerated course
 
coinfected patients
 
control subjects
 
Elevated IP-10 levels
 
HCV-monoinfected
 
HCV-monoinfected patients
 
HCV/HIV-coinfected patients
 
hepatitis C virus
 
HIV-monoinfected patients
 
human immunodeficiency virus
 
IP-10 levels
 
liver disease
 
monoinfected patients
 
patients
 
Serum levels
 
severe liver disease
 
specific chemokine