Affective neuroscience addresses the brain mechanisms underlying emotional behaviour. In psychiatry, affective neuroscience finds application not only in understanding the neurobiology of mood disorders, but also by providing a framework for understanding the neural control of interpersonal and social behaviour and processes that underlie psychopathology. By providing a coherent conceptual framework, affective neuroscience is increasingly able to provide a mechanistic explanatory understanding of current therapies and is driving the development of novel therapeutic approaches.
"This makes them a top priority for biomedical research (Craddock and Forty, 2006; Craddock and Jones, 1999; Veen et al., 2008). Understanding the neural mechanisms of such disorders (Fig. 1A) is an important goal in biological psychiatry (Harrison and Critchley, 2007). A valuable tool for this goal are animal models, commonly used due to their genetic homology with humans, and low cost, time, and space requirements (Crawley, 1999; Sousa et al., 2006). "
[Show abstract][Hide abstract] ABSTRACT: Experimental models are an important tool for the study of biological mechanisms of psychiatric disorders. Although encouraging progress has been made in biological psychiatry of affective disorders, there remain numerous methodological, conceptual, and translational challenges in this field. Mounting clinical data support the view that psychiatric disorders as spectra, rather than as discrete or isolated illnesses. This requires new theories as well as new animal paradigms for "integrative" modeling of psychiatric disorders and their spectra. Here we discuss recent "integrative" experimental models and concepts that promise to advance translational research of affective disorders.
[Show abstract][Hide abstract] ABSTRACT: This brief review summarizes what in the view of the writer represent 10 illustrative authored monographs (as contrasted to edited texts) reflecting the transition of the field of affectiveology into the new millennium. The choice of these books is meant to emphasize the breadth of our field, embracing among others normal emotional life, the clinical descriptive approach, evolutionary biology, genetics, neurobiology, and therapeutics. I may have had some penchant for the unusual--and in this sense this is a very personal list--but my intention was to highlight new developments which are shaping our field.
[Show abstract][Hide abstract] ABSTRACT: There have been numerous exhortations for more 'translational research'. A selective review of historical examples of research leading to health benefits is used to consider the various forms of successful interplay between basic science and clinical applications. This is followed by a consideration of key neuroscience findings that might be relevant for translation, and then by a discussion of the challenges and opportunities in relation to mental disorders. The time-frame for the pathway from science findings to health benefits is usually long, and generally requires an interactive interplay among different scientific strategies. There is a false dichotomy between so-called basic and applied research and translation needs to proceed from the bedside to the laboratory as well as in the opposite direction. There is a key need for bridging research of the hypothesis-testing experimental medicine variety. Health benefits may involve either public health considerations or the treatment of individual patients, or both. There are now some opportunities for direct translational research but there is a much greater need for hypothesis-based bridging studies that occupy a crucial mid-phase in the pathway from science findings to health benefits.
Psychological Medicine 09/2008; 39(4):529-42. DOI:10.1017/S003329170800398X · 5.94 Impact Factor
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