Gynecomastia and premature thelarche: a guide for practitioners.
Division of Pediatric Endocrinology, Department of Pediatrics, Miller School of Medicine, University of Miami, Miami, FL, USA.Pediatrics in Review (Impact Factor: 0.82). 10/2007; 28(9):e57-68. DOI: 10.1542/pir.28-9-e57
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ABSTRACT: Objectives To estimate the association between serum bisphenol A and premature thelarche in female infants aged 4-mo to 2-y. Methods A total of 251 female infants (aged 4 mo to 2 y) with premature thelarche and 33 healthy age-matched control subjects were analyzed. All participants underwent physical examination and serum bisphenol A was measured by ultra-performance liquid chromatography tandem mass spectrometry. Results Serum bisphenol A concentration in the premature thelarche group (3.48 ng/ml, 95%CI: 0.09-140.26) was significantly higher than that in the control group (1.70 ng/ml, 95%CI: 0.06-51.78) (p = 0.039). There was no correlation between age and serum bisphenol A (BPA) level. Univariate logistic regression analysis showed that serum BPA concentration positively associated with premature thelarche, and the effect of BPA fell down as the age grew. Conclusions This hospital-based study implied that there is an association between serum BPA concentrations and premature thelarche. Additionally, serum BPA levels were markedly higher in infants aged 4-mo to 2-y-old, raising a concern for public health authorities.The Indian Journal of Pediatrics 08/2014; 82(3). DOI:10.1007/s12098-014-1548-7 · 0.92 Impact Factor
Article: Adolescent Growth and Development[Show abstract] [Hide abstract]
ABSTRACT: Adolescence is a developmental stage defined by physical and psychosocial maturation. This article reviews normal pubertal development and the evaluation and management of adolescents with suspected pubertal abnormalities and provides an overview of adolescent psychosocial development.Primary Care Clinics in Office Practice 09/2014; 41(3):465–487. DOI:10.1016/j.pop.2014.05.002 · 0.83 Impact Factor
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