Article
Superior vena cava reconstruction using bovine jugular vein conduit.
Department of Thoracic and Cardiovascular Surgery, Second Xiangya Hospital, Central South University, 410011 Hunan, People's Republic of China.
European Journal of Cardio-Thoracic Surgery (impact factor:
2.55).
12/2007;
32(5):816-7.
DOI:10.1016/j.ejcts.2007.07.023
Source: PubMed
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Citations (0)
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Article: Controlled release of chitosan/heparin nanoparticle-delivered VEGF enhances regeneration of decellularized tissue-engineered scaffolds.
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ABSTRACT: Regeneration deficiency is one of the main obstacles limiting the effectiveness of tissue-engineered scaffolds. To develop scaffolds that are capable of accelerating regeneration, we created a heparin/chitosan nanoparticle-immobilized decellularized bovine jugular vein scaffold to increase the loading capacity and allow for controlled release of vascular endothelial growth factor (VEGF). The vascularization of the scaffold was evaluated in vitro and in vivo. The functional nanoparticles were prepared by physical self-assembly with a diameter of 67-132 nm, positive charge, and a zeta potential of ∼30 mV and then the nanoparticles were successfully immobilized to the nanofibers of scaffolds by ethylcarbodiimide hydrochloride/hydroxysulfosuccinimide modification. The scaffolds immobilized with heparin/chitosan nanoparticles exhibited highly effective localization and sustained release of VEGF for several weeks in vitro. This modified scaffold significantly stimulated endothelial cells' proliferation in vitro. Importantly, utilization of heparin/chitosan nanoparticles to localize VEGF significantly increased fibroblast infiltration, extracellular matrix production, and accelerated vascularization in mouse subcutaneous implantation model in vivo. This study provided a novel and promising system for accelerated regeneration of tissue-engineering scaffolds.International Journal of Nanomedicine 01/2011; 6:929-42. · 3.13 Impact Factor
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Keywords
42 months
acceptable alternative
BJVC
glutaraldehyde-treated bovine jugular vein conduit
metastasis
proximal anastomosis
radionuclide venography
slight stenosis
superior vena cava
SVC
SVC obstruction
SVC reconstruction
ventricular outflow tract reconstruction
xenograft conduit