Endemic hantavirus infection impairs the winter survival of its rodent host

University of Helsinki, Helsinki, Uusimaa, Finland
Ecology (Impact Factor: 4.66). 09/2007; 88(8):1911-6. DOI: 10.1890/06-1620.1
Source: PubMed


The influence of pathogens on host fitness is one of the key questions in infection ecology. Hantaviruses have coevolved with their hosts and are generally thought to have little or no effect on host survival or reproduction. We examined the effect of Puumala virus (PUUV) infection on the winter survival of bank voles (Myodes glareolus), the host of this virus. The data were collected by monitoring 22 islands over three consecutive winters (a total of 55 island populations) in an endemic area of central Finland. We show that PUUV infected bank voles had a significantly lower overwinter survival probability than antibody negative bank voles. Antibody negative female bank voles from low-density populations living on large islands had the highest survival. The results were similar at the population level as the spring population size and density were negatively correlated with PUUV prevalence in the autumn. Our results provide the first evidence for a significant effect of PUUV on host survival suggesting that hantaviruses, and endemic pathogens in general, deserve even more attention in studies of host population dynamics.

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Available from: Eva R Kallio, Sep 29, 2015
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    • "A bank vole's survival is compromised by multiple factors including ecto-and endoparasites, disease, starvation, and predation (Kallio et al., 2007; Norrdahl & Korpimäki, 1995; Soveri et al., 2000). For instance, Puumala Hantavirus, Ixodes-tick transmitted pathogens, helminthes, and coccidiosis are all pathogens that compromise bank vole survival (Hakkarainen et al., 2007; Haukisalmi & Henttonen, 2000; Kallio et al., 2007; Soveri et al., 2000). Genetic disease resistance and immune response therefore have important consequences for survival and thus, fitness in this species. "
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    • "The risk for PUUV transfer from the bank vole to the human population via excretion of the virus in the environment is dependent on a myriad of biotic and abiotic risk factors, either rodent-, virus-or human-related, that vary in time and space. In a study from Finland, the effect of PUUV infection on the winter survival of bank voles was investigated (Kallio et al. 2007). These authors demonstrate that PUUV infected bank voles had a significantly lower overwinter survival probability than antibody negative bank voles. "
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    • "Parasites can alter host physiology (Schall et al. 1982; Simon et al. 2004), body condition (Hakkarainen et al. 2007; Vandegrift et al. 2008; Turner et al. 2012), behavior (Schall et al. 1982; Goodman and Johnson 2011), social dominance (Schall and Houle 1992; Zohar and Holmes 1998), and life history (Schall 1983; Schall and Dearing 1987; Shields and Wood 1993; Merino and Potti 1995; Lochmiller and Deerenberg 2000; Skarstein et al. 2001; Chadwick and Little 2005; Cox and John-Alder 2007; Kallio et al. 2007), leading to complex ecological and evolutionary consequences in host populations (Hamilton and Zuk 1982; Buckling and Rainey 2002; Chadwick and Little 2005). Theoretical and field studies suggest that parasites can regulate host populations, playing a role comparable to predators (May and Anderson 1979; Albon et al. 2002; Redpath et al. 2006; Lemaître et al. 2009). "
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