"Individuals who took vitamin D at daily doses ranging from 300 to 2000 IU (average dose 528 IU) for an average of 5.7 years had a 7% lower risk of death (from all causes) than those who did not. The editorial that accompanied the report of the meta-analysis suggested that the relatively low dose of vitamin D and the short treatment period may have led to an underestimation of its effect on the clinical evolution of chronic conditions such as CVD and cancer, as well as of the overall improvement in the immune system and of the vascular protection afforded . A systematic review of 17 prospective studies and randomized trials examining supplementation with vitamin D, calcium, or both and subsequent cardiovascular events concluded that vitamin D supplementation may reduce the risk of CVD. "
[Show abstract][Hide abstract] ABSTRACT: Low serum 25-hydroxyvitamin D (25[OH]D) levels are common and may be associated with morbidity and mortality (and indeed with frailty more generally). This association is not restricted to the links between vitamin D and calcium and bone metabolism.
To review the influences of vitamin D on the aging process other than those related to bone and calcium. Its effect on mortality is also assessed.
The PubMed database was searched for English-language articles relating to vitamin D, using the following MeSH terms: vitamin D, mortality, cardiovascular diseases, and frailty. In addition, searches were carried out with Google.
Although some of the reported results have proved controversial, overall the evidence seems to support an association between low serum 25[OH]D levels and mortality rates (all-cause and cardiovascular). Frailty is a condition frequently associated with low serum 25[OH]D levels.
The aging process and mortality are associated with low vitamin D levels. Prospective controlled trials are warranted to determine whether vitamin D supplements can increase longevity and reduce the incidence of certain conditions.
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