Article

Effector functions of pathogenic Yersinia species.

Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Diagnostikzentrum, Universitätsklinikum Eppendorf, Martinistr. 52, 20246 Hamburg, Germany.
Thrombosis and Haemostasis (impact factor: 5.04). 10/2007; 98(3):521-9. pp.521-9
Source: PubMed

ABSTRACT Pathogenic species of the genus Yersinia suppress and reorient the immune system to infect lymphatic tissues, inner organs and at times also the vasculature. For this purpose yersiniae employ a type III secretion system to translocate effector proteins (Yersinia outer proteins; Yops) into immune cells. Yops often exert unique biochemical activities for modulating the activity of Rho GTP-binding proteins, focal adhesion proteins, inflammatory pathways and cell survival/apoptosis. In this review we will put emphasis on the biochemistry, cell- and infection biology of Yersinia effector Yops.

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Keywords

cell survival/apoptosis
 
cell-
 
focal adhesion proteins
 
immune cells
 
immune system
 
infect lymphatic tissues
 
infection biology
 
inner organs
 
modulating
 
Pathogenic species
 
reorient
 
Rho GTP-binding proteins
 
translocate effector proteins
 
type III secretion system
 
unique biochemical activities
 
vasculature
 
Yersinia effector Yops
 
Yersinia outer proteins
 
Yops
 

Martin Aepfelbacher