Article

Comparative spectroscopic and electrochemical study of nitroindazoles: 3-alcoxy, 3-hydroxy and 3-oxo derivatives.

Departamento de Química Inorgánica y Analítica, Facultad de Ciencias Químicas y Farmacéuticas, Universidad de Chile, Chile.
Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy (Impact Factor: 1.98). 09/2008; 70(3):557-63. DOI: 10.1016/j.saa.2007.07.052
Source: PubMed

ABSTRACT Cyclic voltammetry and electron spin resonance techniques were used in the investigation of novel 3-alkoxy- and 3-hydroxy-1-[omega-(dialkylamino)alkyl]-5-nitroindazole derivatives. A self-protonation process involving the protonation of the nitro group was observed. The reactivity of the nitro-anion radical for these derivatives with glutathione, a biological relevant thiol, was also studied by cyclic voltammetry. These studies demonstrated that glutathione could react with radical species from 5-nitroindazole system. Also we demonstrated that nitro-anion radicals show three different patterns of delocalization where the indazole 1-lateral chain does not have major influence.

0 Bookmarks
 · 
115 Views

Full-text (2 Sources)

View
35 Downloads
Available from
Jun 4, 2014