Increased renal vascular resistance in dogs with hepatic disease

Animal Medicine and Surgery Department, Veterinary Teaching Hospital, Autonomous University of Barcelona, Spain.
The Veterinary Journal (Impact Factor: 1.76). 10/2007; 178(2):257-62. DOI: 10.1016/j.tvjl.2007.07.026
Source: PubMed

ABSTRACT Doppler ultrasound is a non-invasive technique that can be used to estimate vascular resistance by calculation of resistive index (RI) and pulsatility index (PI). Liver disease may increase renal RI and PI, and in humans with liver disease the indices are monitored to attain prognostic information. Systemic hypertension has been found in dogs with hepatic disease and is also related to increased renal vascular resistance in humans. The aim of this study was to examine renal vascular resistance increases in dogs with hepatic disease and to ascertain whether these may be related to blood pressure increases and biochemical parameters. Twenty dogs with hepatic disease were evaluated. The mean renal RI, PI, and systolic blood pressure were significantly higher than in normal animals. A positive correlation was found between the indices and alkaline phosphatase but not with systolic blood pressure. It is concluded that renal vascular resistance may increase in dogs with hepatic disease and in this study was above the limit value in 50% of the animals.

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    • "Sedation or anesthesia may also modify these indices (Novellas et al., 2007). Also, they are related with plasma norepinephrin, aldosteron and renin activity (Sigirci et al., 2006; Novellas et al., 2008). No animals in this study had tension or heart rate problems. "
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    ABSTRACT: Both resistive index (RI) and pulsatility index (PI) estimate vascular resistance within an artery. But, there are only few studies reporting normal values of the renal RI and PI in healthy cats but no study could be found with regard to Turkish Angora breed of cats. So, we decided to determine the normal values of intra-renal RI and PI in non-sedated, non-hypertensive clinically normal Turkish Angora breed cats. For this purpose 20 each of mixed-breed and Turkish Angora breed, different ages and sex healthy cats constituted the study groups. At the result of the pulsed wave doppler ultrasonographic examinations mean values for RI and PI were 0.61±0.04 and 0.97±0.17 for mixed-breed cats; 0.60±0.07 and 1.16±0.34 for Turkish Angora breed cats were recorded, respectively. No significant differences were noted between the groups. At the result, we determined that, they were in normal limits as previously described in clinically healthy Turkish Angora breed of cats.
    Pakistan Veterinary Journal 01/2011; 31(4):369-370. · 1.39 Impact Factor
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    ABSTRACT: The renal resistive index (RI) value of 0.73 has been proposed as the upper limit in normal adult dogs. In humans, changes in RI with age are associated with plasma renin activity. There are relatively few equivalent reference data for dogs. We obtained reference RI data from 22 clinically healthy dogs <4 months of age and 33 healthy dogs between 4 months and 7 years of age. An association between the RI and plasma renin activity was investigated. The mean RI in the older dogs was 0.65 +/- 0.05 vs. 0.75 +/- 0.05 in dogs <4 months of age. The mean plasma renin activity in the older dogs was 1.18 +/- 1.03 vs. 4.23 +/- 3.09 ng/ml/h in dogs <4 months of age. There was a weak linear relationship between the RI and plasma renin activity (r2 = 0.280, P < 0.01) in dogs <4 months of age. Also in these younger dogs, RI was negatively correlated with age (r2 = 0.682, P < 0.01). The RI was higher in dogs <4 months of age than in older dogs. Therefore, the mean renal RI is slightly higher in young dogs than reported for an older population and interpretation of the RI must include an assessment of patient age.
    Veterinary Radiology &amp Ultrasound 05/2010; 51(3):335-7. DOI:10.1111/j.1740-8261.2010.01669.x · 1.45 Impact Factor
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    ABSTRACT: Canine babesiosis is a tick-borne disease with a worldwide distribution that can involve multiple organs and result in a wide variety of clinical manifestations. Our goal was to describe the sonographic changes occurring in 72 dogs naturally infected with babesiosis. Seven healthy Beagle dogs were used as a control group. The most common finding in all dogs was splenomegaly with a diffuse heterogenic parenchyma and generally reduced echogenicity. Diffuse hypoechoic hepatomegaly and bilaterally increased cortical echogenicity of the renal parenchyma were found more frequently in severe uncomplicated and complicated babesiosis groups. Mean renal resistive index and pulsatility index (PI) values were 0.66/1.35, 0.73/1.91, and 0.71/1.73 for mild uncomplicated, severe uncomplicated, and complicated babesiosis groups, respectively. A markedly increased PI for complicated and severe uncomplicated groups correlated with anemia and severity of renal damage. Ultrasonography can be an adjunct for diagnosis and monitoring canine babesiosis and its systemic complications. The detection of diffuse heterogeneous splenomegaly can support the diagnosis of Babesia infection, because of the high prevalence of this lesion in these patients.
    Veterinary Radiology &amp Ultrasound 05/2011; 52(3):323-9. DOI:10.1111/j.1740-8261.2010.01775.x · 1.45 Impact Factor
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