Phyllodes tumour of the breast: Clinical follow-up of 33 cases of this rare disease

Department of Obstetrics and Gynecology, University Hospital Munich, Ludwig-Maximilians-University of Munich, Grosshadern, Marchioninistrasse 15, Munich, Germany.
European Journal of Obstetrics & Gynecology and Reproductive Biology (Impact Factor: 1.7). 07/2008; 138(2):217-21. DOI: 10.1016/j.ejogrb.2007.08.002
Source: PubMed


The "cystosarcoma phyllodes" of the breast is a rare entity which accounts for 0.5% of all breast neoplasms. The aim of our study was to analyse the clinical management with respect to patient outcome.
The data of 5270 patients with primary breast neoplasms treated in our department between 1984 and 2005 were retrospectively analysed for the histopathologic diagnosis of a cystosarcoma phyllodes. The clinical data was analysed with respect to tumour grading and size, treatment and prognosis.
Retrospective analysis of 5270 patients with primary breast neoplasms revealed 33 patients. In the histopathological analysis, tumour grade was classified as benign in 40%, borderline in 27% and malignant in 33% of patients. Breast conserving surgery was conducted in 58% of the patients, mastectomy in 42%. Only one patient was treated with adjuvant radiotherapy after primary surgery. Mean tumour size was 6.9 cm, and no lymph node infiltration was found in the 10 patients who received axillary lymph node dissection. Local recurrence occurred in eight patients (26%). The local recurrence rate was 50% in malignant, 20% in borderline and only 8% in benign tumours. Distant metastases were seen in three patients (9%) with malignant phyllodes tumours. Neither regarding age at primary diagnosis nor in tumour size there was a significant difference between patients with local recurrence or metastatic spread and those without (p=0.284 tumour size; p=0.739 for age; Mann-Whitney U-test).
Histopathological classification appears to be the strongest prognostic factor in this disease.

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    • "Malignant tumors (either low- or high-grade) are common in elderly females and exhibit frequent metastasis (lymphatic and blood-borne) with a high mortality rate (8). Malignant PTs have a high rate of recurrence and the axillary and supraclavicular lymph nodes are commonly enlarged (9). However, 70–90% of all PTs are benign tumors that do not metastasize, although they exhibit continuous growth and rapidly increase in size in a short time. "
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    ABSTRACT: Phyllodes tumors (PTs) of the breast are a rare type of tumor that account for <1% of breast tumors in females and usually present as a large lump of 3-5 cm in size. Surgery is the first line of treatment for PTs, and chemotherapy and irradiation may be useful in certain patients but not all. In the present study, the case of a 63-year-old female patient with a huge PT in the left breast is described. On physical examination, the patient presented with a huge mass of ∼45 cm in diameter, weighing ∼11 kg, and a composite of multiple chronic diseases. The breast and pectoris major and minor were excised. Post-operatively, the patient recovered well and to date there has been no evidence of local recurrence or distant metastasis.
    Oncology letters 07/2013; 6(1):150-152. DOI:10.3892/ol.2013.1361 · 1.55 Impact Factor
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    Wiadomości lekarskie (Warsaw, Poland: 1960) 09/1975; 28(16):1415-6.
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    ABSTRACT: Phyllodes tumours constitute 2-3 percent of fibroepithelial breast tumours, with a 1-2 percent rate of malignancy. Metastasis is usually haematogeneous, and axillary lymph node dissection is not routinely performed. Carcinoma in a phyllodes tumour is distinctly uncommon, but has been known to occur in benign phyllodes tumours. We describe a 51-year-old woman with a malignant phyllodes tumour with foci of intraductal carcinoma within the tumour and adjacent breast tissue. Though the carcinoma was found to be invasive based on the presence of carcinomatous lymph node metastasis, extensive sampling did not yield an invasive component within the breast, probably because of the marked stromal overgrowth of the phyllodes. A malignant phyllodes tumour with foci of intraductal carcinoma and axillary lymph node metastases was diagnosed rather than carcinosarcoma. Chemotherapy and irradiation were included in the postoperative management. Coexistence of phyllodes tumour and carcinoma is rare, and extensive sampling may be necessary to find the foci of carcinoma within an extensive and obviously malignant stromal overgrowth. There is little consensus on the treatment and prognosis in these cases, and it is recommended that treatment be tailored to individual patients, based on the presence of invasion, lymph node metastasis and/or distant metastasis.
    Singapore medical journal 12/2008; 49(11):e318-21. · 0.60 Impact Factor
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