Clozapine-related agranulocytosis associated with fever of unknown origin, protective hospitalisation, and multiple adverse events related to the administration of empiric antimicrobial treatment

Department of Clinical and Experimental Medicine, Division of Infectious Diseases, Alma Mater Studiorum University of Bologna, S. Orsola-Malpighi Hospital, Bologna, Italy.
Pharmacoepidemiology and Drug Safety (Impact Factor: 2.94). 12/2007; 16(12):1285-9. DOI: 10.1002/pds.1476
Source: PubMed


An exemplary case report of a patient who developed an unpredictable sudden, late-onset clozapine-related life-threatening agranulocytosis expressed by a nadir of 14 polymorphonuclear cells/mu L, and subsequently underwent protective hospitalisation and broad spectrum, empiric antimicrobial therapy and also experienced serious intolerance to a number of administered antibiotic and antifungal agents, is reported and discussed on the grounds of the available evidence from the literature. Copyright (c) 2007 John Wiley & Sons, Ltd.

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