An efficient and mild bismuth triflate-catalysed three-component Mannich-type reaction

Département de Chimie, Université Laval, Québec, Canada.
Organic & Biomolecular Chemistry (Impact Factor: 3.56). 11/2007; 5(19):3126-34. DOI: 10.1039/b710794c
Source: PubMed


In the presence of a catalytic amount of Bi(OTf)(3).4H(2)O, aldehydes together with amines react with silyl enolates to afford the corresponding Mannich-type adducts smoothly. A wide variety of silyl enolates derived from ketones, as well as esters and thioesters, react rapidly to afford the beta-amino ketones or the beta-amino esters in high yields (up to 94%).

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